umu.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
How is disease severity associated with quality of life in psoriasis patients?: Evidence from a longitudinal population-based study in Sweden
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Dermatology and Venerology. PAREXEL Int, Stockholm, Sweden.
Linköping Univ, Dept Med & Hlth Sci, Linköping, Sweden.
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Dermatology and Venerology.ORCID iD: 0000-0002-3858-8474
2017 (English)In: Health and Quality of Life Outcomes, ISSN 1477-7525, E-ISSN 1477-7525, Vol. 15, no 1, article id 151Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Assessing the impact of disease severity on generic quality of life (QOL) is a critical step in outcomes research and in the development of decision-analytic models structured around health states defined by clinical measures. While data from routine clinical practice found in healthcare registers are increasingly used for research, more attention should be paid to understanding the relationship between clinical measures of disease severity and QOL. The purpose of this work was therefore to investigate this relationship in psoriasis using a population-based dataset.

METHODS: Severity was measured by the Psoriasis Area and Severity Index (PASI), which combines severity of erythema, induration, and desquamation into a single value ranging from 0 to 72. The generic EQ-5D-3L utility instrument, under the UK tariff, was used to measure QOL. The association between PASI and EQ-5D-3L was estimated using a population-based dataset of 2674 patients with moderate to severe psoriasis enrolled over ten years in the Swedish psoriasis register (PsoReg). Given the repeated measurement of patients in the register data, a longitudinal fixed-effects model was employed to control for unobserved patient-level heterogeneity.

RESULTS: Marginal changes in PASI are associated with a non-linear response in EQ-5D-3L: Moving from PASI 10 to 9 (1 to 0) is associated with an increase of 0.0135 (0.0174) in EQ-5D-3L. Furthermore, unobserved patient-level heterogeneity appears to be an important source of confounding when estimating the relationship between QOL and PASI.

CONCLUSIONS: Using register data to estimate the impact of disease severity on QOL while controlling for unobserved patient-level heterogeneity shows that PASI appears to have a larger impact on QOL than previously estimated. Routine collection of generic QOL data in registers should be encouraged to enable similar applications in other disease areas.

Place, publisher, year, edition, pages
2017. Vol. 15, no 1, article id 151
Keywords [en]
Quality of life, EQ-5D; Disease severity, Population-based data, Register data, Psoriasis
National Category
Health Care Service and Management, Health Policy and Services and Health Economy
Research subject
Dermatology and Venerology
Identifiers
URN: urn:nbn:se:umu:diva-138071DOI: 10.1186/s12955-017-0721-xISI: 000406615700001PubMedID: 28754116OAI: oai:DiVA.org:umu-138071DiVA, id: diva2:1129683
Available from: 2017-08-06 Created: 2017-08-06 Last updated: 2018-06-09Bibliographically approved

Open Access in DiVA

fulltext(1976 kB)46 downloads
File information
File name FULLTEXT01.pdfFile size 1976 kBChecksum SHA-512
4e14d8b3d47bb8d7d0515f42366b5169712063f751ccbbf83dc3a33673e3c62f246d3a8190d1ef3cc94d4070c108af92fc3994459a7ebc7a6cd92b997d6b7ea9
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Authority records BETA

Geale, KirkSchmitt-Egenolf, Marcus

Search in DiVA

By author/editor
Geale, KirkSchmitt-Egenolf, Marcus
By organisation
Dermatology and Venerology
In the same journal
Health and Quality of Life Outcomes
Health Care Service and Management, Health Policy and Services and Health Economy

Search outside of DiVA

GoogleGoogle Scholar
Total: 46 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 184 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf