umu.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Voxel-based morphometry multi-center mega-analysis of brain structure in social anxiety disorder
Show others and affiliations
2017 (English)In: NeuroImage: Clinical, ISSN 0353-8842, E-ISSN 2213-1582, Vol. 16, p. 678-688Article in journal (Refereed) Published
Abstract [en]

Social anxiety disorder (SAD) is a prevalent and disabling mental disorder, associated with significant psychiatric comorbidity. Previous research on structural brain alterations associated with SAD has yielded inconsistent results concerning the direction of the changes in graymatter (GM) in various brain regions, as well as on the relationship between brain structure and SAD-symptomatology. These heterogeneous findings are possibly due to limited sample sizes. Multisite imaging offers new opportunities to investigate SAD-related alterations in brain structure in larger samples. An international multi-center mega-analysis on the largest database of SAD structural T1-weighted 3T MRI scans to date was performed to compare GM volume of SAD-patients (n = 174) and healthy control (HC)-participants (n = 213) using voxel-based morphometry. A hypothesis-driven region of interest (ROI) approach was used, focusing on the basal ganglia, the amygdala-hippocampal complex, the prefrontal cortex, and the parietal cortex. SAD-patients had larger GM volume in the dorsal striatum when compared to HC-participants. This increase correlated positively with the severity of self-reported social anxiety symptoms. No SAD-related differences in GM volume were present in the other ROIs. Thereby, the results of this mega-analysis suggest a role for the dorsal striatum in SAD, but previously reported SAD-related changes in GM in the amygdala, hippocampus, precuneus, prefrontal cortex and parietal regions were not replicated. Our findings emphasize the importance of large sample imaging studies and the need for meta-analyses like those performed by the Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) Consortium.

Place, publisher, year, edition, pages
Elsevier, 2017. Vol. 16, p. 678-688
Keywords [en]
Social anxiety disorder, Structural MRI, Voxel-based morphometry, Gray matter, Mega-analysis, Striatum
National Category
Psychiatry Neurosciences
Identifiers
URN: urn:nbn:se:umu:diva-138294DOI: 10.1016/j.nicl.2017.08.001ISI: 000413235100071OAI: oai:DiVA.org:umu-138294DiVA, id: diva2:1133862
Available from: 2017-08-17 Created: 2017-08-17 Last updated: 2018-06-09Bibliographically approved

Open Access in DiVA

fulltext(1084 kB)73 downloads
File information
File name FULLTEXT01.pdfFile size 1084 kBChecksum SHA-512
ba6b4ead0706cc27a8195ca3d1351e2f9db71c4d595d95b62920ec992f6063286c1b34786c46ef5d7649e62eacd5ccf7577906a78c6bf1370f90dbc21253da35
Type fulltextMimetype application/pdf

Other links

Publisher's full text

Authority records BETA

Boraxbekk, Carl-Johan

Search in DiVA

By author/editor
Boraxbekk, Carl-Johan
By organisation
Umeå Centre for Functional Brain Imaging (UFBI)
In the same journal
NeuroImage: Clinical
PsychiatryNeurosciences

Search outside of DiVA

GoogleGoogle Scholar
Total: 73 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
urn-nbn

Altmetric score

doi
urn-nbn
Total: 353 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf