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Network analysis of Se-and Zn-related proteins in the serum proteomics expression Ppofile of the endemic dilated cardiomyopathy Keshan disease.
School of Public Health, Health Science Center of Xi'an Jiaotong University, Xi'an, China; Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, Xi'an, China.
Department of Rheumatology, Xi'an No.5 Hospital, Xi'an, China.
School of Public Health, Health Science Center of Xi'an Jiaotong University, Xi'an, China; Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, Xi'an, China.
School of Public Health, Health Science Center of Xi'an Jiaotong University, Xi'an, China; Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, Xi'an, China.
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2017 (English)In: Biological Trace Element Research, ISSN 0163-4984, E-ISSN 1559-0720, 28819918Article in journal (Refereed) Epub ahead of print
Abstract [en]

Keshan disease (KD) is an endemic cardiomyopathy with high mortality. Selenium (Se) and zinc (Zn) deficiencies are closely related to KD. The molecular mechanism of KD pathogenesis is still unclear. There are only few studies on the interaction of trace elements and proteins associated with the pathogenesis of KD. In this study, isobaric tags for relative and absolute quantitation (iTRAQ)-coupled two-dimensional liquid chromatography tandem mass spectrometry (2DLC-MS/MS) technique analysis was used to analyze the differential expression of proteins from serum samples. Comparative Toxicogenomics Database (CTD) was used to screen Se- and Zn-associated proteins. Then, pathway and network analyses of Se- and Zn-associated proteins were constituted by Cytoscape ClueGO and GeneMANIA plugins. One hundred and five differentially expressed proteins were obtained by 2DLC-MS/MS, among them 19 Se- and 3 Zn-associated proteins. Fifty-two pathways were identified from ClueGO and 1 network from GeneMANIA analyses. The results showed that Se-associated proteins STAT3 and MAPK1 and Zn-associated proteins HIF1A and PARP1, the proteins involved in HIF-1 signaling pathway and apoptosis pathway, may play significant roles in the pathogenesis of KD. The approach of this study would be also beneficial for further dissecting molecular mechanism of other trace element-associated disease.

Place, publisher, year, edition, pages
Springer, 2017. 28819918
Keyword [en]
Cardiomyocyte, GeneGO, GeneMANIA, Keshan disease, Trace element, iTRAQ
National Category
Cardiac and Cardiovascular Systems Biochemistry and Molecular Biology
Research subject
Biochemistry; Medicine, cardiovascular disease
Identifiers
URN: urn:nbn:se:umu:diva-138316DOI: 10.1007/s12011-017-1063-6PubMedID: 28819918OAI: oai:DiVA.org:umu-138316DiVA: diva2:1134448
Available from: 2017-08-19 Created: 2017-08-19 Last updated: 2017-09-11

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