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Effects of osteopontin-enriched formula on lymphocyte subsets in the first 6 months of life: a randomized controlled trial
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Paediatrics.
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2017 (English)In: Pediatric Research, ISSN 0031-3998, E-ISSN 1530-0447, Vol. 82, no 1, p. 63-71Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Human milk is rich in osteopontin (OPN), which has immunomodulatory functions. METHODS: In a randomized controlled trial, standard formula (SF) and the same formula with 65 mg of OPN/L (F65) or 130 mg of OPN/L (F130), representing similar to 50 and 100% of the OPN concentration in human milk, were compared. We examined frequencies and composition of peripheral blood immune cells by four-color immunoflow cytometry of formula-fed infants at ages 1, 4, and 6 months, and compared them with a breastfed (BF) reference group. RESULTS: The F130 group had increased T-cell proportions compared with the SF (P = 0.036, average effect size 0.51) and F65 groups (P = 0.008, average effect size 0.65). Compared with the BF group, the monocyte proportions were increased in the F65 (P=0.001, average effect size 0.59) and F130 (P=0.006, average effect size 0.50) groups, but were comparable among the formula groups. CONCLUSION: OPN in an infant formula at a concentration close to that of human milk increased the proportion of circulating T cells compared with both SF and formula with added OPN at similar to 50% of the concentration in human milk. This suggests that OPN may favorably influence immune ontogeny in infancy and that the effects appear to be dose-dependent.

Place, publisher, year, edition, pages
Nature Publishing Group, 2017. Vol. 82, no 1, p. 63-71
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Pediatrics
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URN: urn:nbn:se:umu:diva-138423DOI: 10.1038/pr.2017.77ISI: 000406256000012OAI: oai:DiVA.org:umu-138423DiVA, id: diva2:1135487
Available from: 2017-08-23 Created: 2017-08-23 Last updated: 2018-06-09Bibliographically approved

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West, Christina E.

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CiteExportLink to record
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