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Cancer cachexia and the effects of physical activity
Umeå University, Faculty of Medicine, Department of Community Medicine and Rehabilitation, Sports medicine.
Umeå University, Faculty of Medicine, Department of Community Medicine and Rehabilitation, Sports medicine.
Umeå University, Faculty of Medicine, Department of Community Medicine and Rehabilitation, Sports medicine.ORCID iD: 0000-0001-8191-6659
2016 (English)In: Journal of Orthopedic Research & Therapy, J125Article in journal (Refereed) Published
Abstract [en]

Physical activity is, among other things, characterized by an increased quality of life and several physiological positive results such as hypertrophy and counteracting atrophy. Cachexia has been proven to degradate muscle proteins and seems to be a death contributing factor during cancer.Cachectic muscles are resistant to anabolic effects, and this knowledge combined with the many proven positive outcomes on muscle hypertrophy by exercise led this study to investigate the previous studies conducted on this subject further. The Ubiquitin-Proteasome System (UPS) plays a significant role in protein degradation, more specifically the E3 ubiquitin ligases MuRF-1 (Muscle RING Finger protein-1) and MaFbx (Muscle atrophy F-box), which are FoxO (forkhead box-O) transcription factors. The UPS can be inhibited by substrates upregulated by physical activity, such as IGF-1 (Insulin-like Growth Factor-1) and PGC-1α (Peroxisome proliferator-activated receptor gamma coactivator 1-alpha). In conclusion, there are a lot of pathways in both cancer cachexia and physical activity that border on each other, but the molecular mechanisms are complex and not always clear.

Place, publisher, year, edition, pages
2016. J125
Keyword [en]
Muscle Hypertrophy, Muscle Atrophy, Protein Degradation
National Category
Sport and Fitness Sciences
Research subject
Physiology
Identifiers
URN: urn:nbn:se:umu:diva-139075OAI: oai:DiVA.org:umu-139075DiVA: diva2:1138757
Available from: 2017-09-06 Created: 2017-09-06 Last updated: 2017-09-06

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http://gavinpublishers.com/wp-content/uploads/2017/05/JORT-125.pdf

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CiteExportLink to record
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Citation style
  • apa
  • ieee
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  • Other style
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Language
  • de-DE
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  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
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  • Other locale
More languages
Output format
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  • text
  • asciidoc
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