umu.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Quantification of atherosclerotic plaque area by vascular ultrasound: reproducibility and comparison between conventional B-mode imaging and contrast-enhanced ultrasound
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine.
(English)Manuscript (preprint) (Other academic)
Abstract [en]

Background: Quantification of plaque burden represents a significant challenge to clinical practices, however, innovations in technologies, techniques and methodologies play a significant role in plaque assessment and burden quantification. Plaque area determination represents a useful method for quantifying atherosclerosis but poor visualization of plaques remains an issue that may significantly restrict its use. Contrast enhanced ultrasound (CEUS) has been proposed as a technique to improve the visualization of atherosclerotic plaques, however, blooming artefacts inherent to the CEUS technique, and which are known to vary depending on the intensity of the enhancement, may lead to an underestimation of the true plaque area.

We hypothesised that plaque area measurements using CEUS will improve reproducibility of plaque area quantification, and that this will be independent of the time at which the image is acquired post-contrast administration when compared with conventional B-mode imaging. In this study, the areas of 42 carotid plaques from 33 subjects (18 men, mean age 61.3 ± 3.02 years) were measured offline. A series of four image loops were acquired for each study: first a conventional B-mode image, then 3 separate CEUS image loops at 5, 10 and 15 seconds post-contrast administration. Also, two expert operators (A and B) performed measurements to assess for inter-observer variability.

Results: We found a strong correlation between B-mode plaque area measurements and CEUS plaque area measurements performed at 5 (T5, ICC=0.998), 10 (T10, ICC=0.999) and 15 (T15, ICC=0.998) seconds post contrast administration. The ICC for intra-observer variability was 0.99 for operator A, and 0.98 for operator B. The ICC for inter-observer variability was 0.96 for B-mode measurements, and 0.98, 0.98 and 0.99, respectively, for CEUS measurements at T5, T10 and T15.

Conclusion: This study showed a strong consensus between B-mode and CEUS images. Blooming artefacts, inherent to the CEUS imaging technique, do not seem to significantly affect the measurement of plaque area in comparison to conventional B-mode imaging.

National Category
Other Medical Sciences not elsewhere specified
Identifiers
URN: urn:nbn:se:umu:diva-139771OAI: oai:DiVA.org:umu-139771DiVA: diva2:1143620
Available from: 2017-09-21 Created: 2017-09-21 Last updated: 2017-09-21

Open Access in DiVA

No full text

By organisation
Department of Public Health and Clinical Medicine
Other Medical Sciences not elsewhere specified

Search outside of DiVA

GoogleGoogle Scholar

Total: 3 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf