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Harnessing LRIG1-mediated inhibition of receptor tyrosine kinases for cancer therapy
Umeå University, Faculty of Medicine, Department of Radiation Sciences.
2017 (English)In: Biochimica et Biophysica Acta, ISSN 0006-3002, E-ISSN 1878-2434, Vol. 1868, no 1, 109-116 p.Article, review/survey (Refereed) Published
Abstract [en]

Leucine-rich repeats and immunoglobulin-like domains containing protein 1 (LRIG1) is an endogenous feedback regulator of receptor tyrosine kinases (RTKs) and was recently shown to inhibit growth of different types of malignancies. Additionally, this multifaceted RTK inhibitor was reported to be a tumor suppressor, a stem cell regulator, and a modulator of different cellular phenotypes. This mini-review provides a concise and up-to-date summary about the known functions of LRIG1 and its related family members, with a special emphasis on underlying molecular mechanisms and the opportunities for harnessing its therapeutic potential against cancer. 

Place, publisher, year, edition, pages
Elsevier, 2017. Vol. 1868, no 1, 109-116 p.
Keyword [en]
Leucine-rich repeats and immunoglobulin-like domains containing protein 1, Receptor tyrosine nase, Ectodomain, Nervous system, Cancer
National Category
Cancer and Oncology
Identifiers
URN: urn:nbn:se:umu:diva-139822DOI: 10.1016/j.bbcan.2017.02.007ISI: 000408783200010PubMedID: 28259645OAI: oai:DiVA.org:umu-139822DiVA: diva2:1144225
Available from: 2017-09-25 Created: 2017-09-25 Last updated: 2017-09-25Bibliographically approved

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