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Using Functional Magnetic Resonance Imaging to Detect Chronic Fatigue in Patients With Previous Traumatic Brain Injury: changes linked to altered Striato-Thalamic-Cortical Functioning
Umeå University, Faculty of Medicine, Department of Community Medicine and Rehabilitation, Geriatric Medicine.
Umeå University, Faculty of Medicine, Department of Community Medicine and Rehabilitation, Geriatric Medicine.
Umeå University, Faculty of Medicine, Umeå Centre for Functional Brain Imaging (UFBI). Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB), Physiology. Karolinska Inst, Dept Neurobiol Care Sci & Soc, Stockholm, Sweden.
Umeå University, Faculty of Medicine, Umeå Centre for Functional Brain Imaging (UFBI). Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB), Physiology.
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2018 (English)In: The journal of head trauma rehabilitation, ISSN 0885-9701, E-ISSN 1550-509X, Vol. 33, no 4, p. 266-274Article in journal (Refereed) Published
Abstract [en]

Objective: To investigate whether functional magnetic resonance imaging (fMRI) can be used to detect fatigue after traumatic brain injury (TBI).

Setting: Neurorehabilitation clinic.

Participants: Patients with TBI (n = 57) and self-experienced fatigue more than 1 year postinjury, and age- and gender-matched healthy controls (n = 27).

Main Measures: Self-assessment scales of fatigue, a neuropsychological test battery, and fMRI scanning during performance of a fatiguing 27-minute attention task.

Results: During testing within the fMRI scanner, patients showed a higher increase in self-reported fatigue than controls from before to after completing the task (P < .001).The patients also showed lower activity in several regions, including bilateral caudate, thalamus, and anterior insula (all P < .05). Furthermore, the patients failed to display decreased activation over time in regions of interest: the bilateral caudate and anterior thalamus (all P < .01). Left caudate activity correctly identified 91% of patients and 81% of controls, resulting in a positive predictive value of 91%.

Conclusion: The results suggest that chronic fatigue after TBI is associated with altered striato-thalamic-cortical functioning. It would be of interest to study whether fMRI can be used to support the diagnosis of chronic fatigue in future studies.

Place, publisher, year, edition, pages
Wolters Kluwer, 2018. Vol. 33, no 4, p. 266-274
Keywords [en]
fatigue, functional magnetic resonance imaging, neuropsychology, traumatic brain injury
National Category
Neurology
Research subject
Rehabilitation Medicine
Identifiers
URN: urn:nbn:se:umu:diva-140021DOI: 10.1097/HTR.0000000000000340ISI: 000442745900013OAI: oai:DiVA.org:umu-140021DiVA, id: diva2:1145486
Funder
Västerbotten County CouncilTorsten Söderbergs stiftelseAvailable from: 2017-09-29 Created: 2017-09-29 Last updated: 2018-09-11Bibliographically approved

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Berginström, NilsNordström, PeterEkman, UrbanEriksson, JohanAndersson, MicaelNyberg, LarsNordström, Anna

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Berginström, NilsNordström, PeterEkman, UrbanEriksson, JohanAndersson, MicaelNyberg, LarsNordström, Anna
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Geriatric MedicineUmeå Centre for Functional Brain Imaging (UFBI)PhysiologyDepartment of Radiation SciencesOccupational and Environmental Medicine
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