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Gender differences in Parkinson's disease: a clinical perspective
Umeå University, Faculty of Medicine, Department of Community Medicine and Rehabilitation, Occupational Therapy. Department of Neurology, University Clinical Centre Ljubljana, Ljubljana, Slovenia; Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, London, UK.
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Family Medicine.ORCID iD: 0000-0002-9271-9260
Umeå University, Faculty of Medicine, Department of Pharmacology and Clinical Neuroscience, Clinical Neuroscience. Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, London, UK.
Umeå University, Faculty of Medicine, Department of Pharmacology and Clinical Neuroscience, Clinical Neuroscience.
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2017 (English)In: Acta Neurologica Scandinavica, ISSN 0001-6314, E-ISSN 1600-0404, Vol. 136, no 6, p. 570-584Article in journal (Refereed) Published
Abstract [en]

Available data indicate that there are gender differences in many features of Parkinson's disease (PD). Precise identification of the gender differences is important to tailor treatment, predict outcomes, and meet other individual and social needs in women and men with PD. The aim of this study was to review the available clinical data on gender differences in PD. Original articles and meta-analyses published between 1990 and 2016 systematically exploring gender differences in PD were reviewed. There is slight male preponderance in incidence and prevalence of PD. PD starts earlier in men. Women tend to be more prone to develop tremor-dominant PD but are less rigid than men. Motor improvement after deep brain stimulation is equal in both sexes, but women tend to show better improvement in activities of daily living. Furthermore, women with PD show better results on tests for general cognitive abilities, outperform men in verbal cognitive tasks, show more pain symptoms, and score higher on depression scales. It seems, however, that the differences in cognition, mood, and pain perception are not disease specific as similar gender differences can be found in healthy subjects and in other neurological conditions. Despite PD being the most frequently studied movement disorder, studies investigating gender differences in PD are still scarce with most of the studies being cross-sectional. Good-quality, prospective, longitudinal studies analyzing gender differences in PD and comparing them to matched healthy controls are needed in order to properly address the issues of gender differences in PD.

Place, publisher, year, edition, pages
John Wiley & Sons, 2017. Vol. 136, no 6, p. 570-584
Keywords [en]
activities of daily living, gender differences, motor symptoms, non-motor symptoms, Parkinson's disease, quality of life
National Category
Neurology
Identifiers
URN: urn:nbn:se:umu:diva-140684DOI: 10.1111/ane.12796ISI: 000414488000002PubMedID: 28670681OAI: oai:DiVA.org:umu-140684DiVA, id: diva2:1149540
Available from: 2017-10-16 Created: 2017-10-16 Last updated: 2018-06-09Bibliographically approved

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Georgiev, DejanHamberg, KatarinaHariz, MarwanForsgren, LarsHariz, Gun-Marie

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Georgiev, DejanHamberg, KatarinaHariz, MarwanForsgren, LarsHariz, Gun-Marie
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