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An overview of benzo[b]thiophene-based medicinal chemistry
Umeå University, Faculty of Science and Technology, Department of Chemistry.
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2017 (English)In: European Journal of Medicinal Chemistry, ISSN 0223-5234, E-ISSN 1768-3254, Vol. 138, p. 1002-1033Article, review/survey (Refereed) Published
Abstract [en]

Among sulfur containing heterocycles, benzothiophene and its derivatives are at the focus as these candidates have structural similarities with active compounds to develop new potent lead molecules in drug design. Benzo[b]thiophene scaffold is one of the privileged structures in drug discovery as this core exhibits various biological activities allowing them to act as anti-microbial, anti-cancer, anti-inflammatory, anti-oxidant, anti-tubercular, anti-diabetic, anti-convulsant agents and many more. Further, numerous benzothiophene-based compounds as clinical drugs have been extensively used to treat various types of diseases with high therapeutic potency, which has led to their extensive developments. Due to the wide range of biological activities of benzothiophene, their structure activity relationships (SAR) have generated interest among medicinal chemists, and this has culminated in the discovery of several lead molecules against numerous diseases. The present review is endeavoring to highlight the progress in the various pharmacological activities of benzo[b]thiophene derivatives. It is hoped that this review will be helpful for new thoughts in the quest for rational designs of more active and less toxic benzothiophene-based medicinal drugs, as well as more effective diagnostic agents and pathologic probes. Also, SAR studies that highlight the chemical groups responsible for evoking the potential activities of benzothiophene derivatives are studied and compared.

Place, publisher, year, edition, pages
Elsevier Masson SAS , 2017. Vol. 138, p. 1002-1033
Keywords [en]
Heterocyclic compound, Benzothiophene, Synthesis, Anti-microbial, Anti-cancer, SAR study
National Category
Medicinal Chemistry
Identifiers
URN: urn:nbn:se:umu:diva-140647DOI: 10.1016/j.ejmech.2017.07.038ISI: 000411297000078PubMedID: 28759875OAI: oai:DiVA.org:umu-140647DiVA, id: diva2:1150143
Available from: 2017-10-18 Created: 2017-10-18 Last updated: 2018-06-09Bibliographically approved

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Chand, Karam

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CiteExportLink to record
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