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Bioaccumulation of psychoactive pharmaceuticals in fish in an effluent dominated stream
Umeå University, Faculty of Science and Technology, Department of Chemistry.
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2017 (English)In: Water Research, ISSN 0043-1354, E-ISSN 1879-2448, Vol. 124, p. 654-662Article in journal (Refereed) Published
Abstract [en]

The treated effluent from sewage treatment plants (STP) is a major source of active pharmaceutical ingredients (APIs) that enter the aquatic environment. Bioaccumulation of 11 selected psychoactive pharmaceuticals (citalopram, clomipramine, haloperidol, hydroxyzine, levomepromazine, mianserin, mirtazapine, paroxetine, sertraline, tramadol and venlafaxine) was examined in Zivny Stream (tributary of the Blanice River, the Czech Republic), which is a small stream highly affected by effluent from the Prachatice STP. Six of the 11 pharmaceuticals were detected in grab water samples and in passive samplers. All pharmaceuticals were found in fish exposed to the stream for a defined time. The organs with highest presence of the selected pharmaceuticals were the liver and kidney; whereas only one pharmaceutical (sertraline) was detected in the brain of exposed fish. Fish plasma and muscle samples were not adequate in revealing exposure because the number of hits was much lower than that in the liver or kidney. Using the criterion of a bioaccumulation factor (BAF) >= 500, citalopram, mianserin, mirtazapine and sertraline could be classified as potential bioaccumulative compounds. In combination, data from integrative passive samplers and fish liver or kidney tissue samples were complimentary in detection of target compounds and simultaneously helped to distinguish between bioconcentration and bioaccumulation.

Place, publisher, year, edition, pages
PERGAMON-ELSEVIER SCIENCE LTD , 2017. Vol. 124, p. 654-662
Keywords [en]
Brown trout, Contamination, Sewage water, Antidepressant, Real exposure
National Category
Environmental Sciences Analytical Chemistry
Identifiers
URN: urn:nbn:se:umu:diva-140875DOI: 10.1016/j.watres.2017.08.018ISI: 000412251500064PubMedID: 28825984OAI: oai:DiVA.org:umu-140875DiVA, id: diva2:1158432
Available from: 2017-11-20 Created: 2017-11-20 Last updated: 2018-06-09Bibliographically approved

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Grabicova, KaterinaFick, Jerker

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