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The evolutionary transition from uracil to thymine balances the genetic code
Umeå University, Faculty of Social Sciences, Centre for Demographic and Ageing Research (CEDAR).ORCID iD: 0000-0001-9188-5518
1996 (English)In: Journal of Chemometrics, ISSN 0886-9383, E-ISSN 1099-128X, Vol. 10, p. 163-170Article in journal (Refereed) Published
Abstract [en]

A multivariate quantitative physicochemical characterization of the five bases adenine (A), cytosine (C), guanine (G), thymine (T) and uracil (U), followed by principal component analysis, shows that the relative dissimilarities between the bases of DNA (A, C, G and T) are almost the same (i.e. balanced). In contrast, mRNA (containing U instead of T) has a considerably larger relative physicochemical similarity between C and U than between all other pairs of bases and is therefore inherently more unbalanced. These results provide a physicochemical explanation of the presence of thymine instead of uracil as an element of DNA. The principal component scores enable a quantitative description of nucleic acid sequence data to be made for structure-activity modelling purposes.

Place, publisher, year, edition, pages
John Wiley & Sons, 1996. Vol. 10, p. 163-170
Keywords [en]
multivariate characterization, DNA, nucleotides
National Category
Organic Chemistry
Identifiers
URN: urn:nbn:se:umu:diva-142533DOI: 10.1002/(SICI)1099-128X(199603)10:2<163::AID-CEM415>3.0.CO;2-SOAI: oai:DiVA.org:umu-142533DiVA, id: diva2:1161991
Available from: 2017-12-01 Created: 2017-12-01 Last updated: 2018-06-09
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Sandberg Hiltunen, Maria

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