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Differences in the coronal proteome acquired by particles depositing in the lungs of asthmatic versus healthy humans
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2017 (English)In: Nanomedicine: Nanotechnology, Biology and Medicine, ISSN 1549-9634, E-ISSN 1549-9642, Vol. 13, no 8, p. 2517-2521Article in journal (Refereed) Published
Abstract [en]

Most inhaled nanomedicines in development are for the treatment of lung disease, yet little is known about their interaction with the respiratory tract lining fluids (RTLFs). Here we combined the use of nano-silica, as a protein concentrator, with label-free snapshot proteomics (LC-MS/MS; key findings confirmed by ELISA) to generate a quantitative profile of the RTLF proteome and provided insight into the evolved corona; information that may be used in future to improve drug targeting to the lungs by inhaled medicines. The asthmatic coronal proteome displayed a reduced contribution of surfactant proteins (SP-A and B) and a higher contribution of alpha 1-antitrypsin. Pathway analysis suggested that asthmatic RTLFs may also be deficient in proteins related to metal handling (e.g. lactoferrin). This study demonstrates how the composition of the corona acquired by inhaled nanoparticles is modified in asthma and suggests depressed mucosal immunity even in mild airway disease.

Place, publisher, year, edition, pages
Elsevier, 2017. Vol. 13, no 8, p. 2517-2521
National Category
Respiratory Medicine and Allergy
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URN: urn:nbn:se:umu:diva-141976DOI: 10.1016/j.nano.2017.06.008ISI: 000414301400013PubMedID: 28647590OAI: oai:DiVA.org:umu-141976DiVA, id: diva2:1163317
Available from: 2017-12-06 Created: 2017-12-06 Last updated: 2018-06-09Bibliographically approved

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Behndig, Annelie F.Blomberg, Anders

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  • de-DE
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