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Patients with high c-MYC-expressing squamous cell carcinomas of the tongue show better survival than those with low- and medium-expressing tumours
Umeå University, Faculty of Medicine, Department of Medical Biosciences, Pathology.
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2017 (English)In: Journal of Oral Pathology & Medicine, ISSN 0904-2512, E-ISSN 1600-0714, Vol. 46, no 10, p. 967-971Article in journal (Refereed) Published
Abstract [en]

Backgroundc-MYC is a potent oncoprotein with roles in a wide range of cellular processes such as differentiation, apoptosis and growth control. Deregulation of the MYC gene is commonly seen in human tumours resulting in overexpression of the protein. Here we studied expression of c-MYC in correlation to clinical outcome in patients with primary squamous cell carcinoma of the mobile tongue. MethodsImmunohistochemistry was used to identify c-MYC in a group of 104 tongue squamous cell carcinomas with an antibody directed against the N-terminal part of the protein. Staining was evaluated by multiplying the percentage of c-MYC-expressing cells with staining intensity, giving a quick score for each tumour. ResultsAll 104 tumours expressed c-MYC at varying levels. Quantitation according to per cent of positive cells and staining intensity revealed that most (15/21; 71%) high-expressing tumours were seen in males. Within the group of high c-MYC-expressing tumours, the majority were alive 2 and 5 years after treatment. ConclusionsThe present findings show that expression of c-MYC has prognostic value in squamous cell carcinoma of the tongue, and could be useful in choice of therapy.

Place, publisher, year, edition, pages
John Wiley & Sons, 2017. Vol. 46, no 10, p. 967-971
Keywords [en]
c-MYC, radiotherapy, squamous cell carcinoma, tongue
National Category
Cancer and Oncology
Identifiers
URN: urn:nbn:se:umu:diva-141977DOI: 10.1111/jop.12579ISI: 000414366000017PubMedID: 28393404OAI: oai:DiVA.org:umu-141977DiVA, id: diva2:1163362
Available from: 2017-12-06 Created: 2017-12-06 Last updated: 2018-06-09Bibliographically approved

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Strindlund, KlasGu, XiaolianBoldrup, LindaFåhraeus, RobinNorberg-Spaak, LenaSaadat, MohammadNylander, Karin

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Strindlund, KlasGu, XiaolianBoldrup, LindaFåhraeus, RobinNorberg-Spaak, LenaSaadat, MohammadNylander, Karin
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Journal of Oral Pathology & Medicine
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