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Crystal structures of OrfX2 and P47 from a Botulinum neurotoxin OrfX-type gene cluster
Umeå University, Faculty of Medicine, Department of Medical Biochemistry and Biophysics.
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2017 (English)In: FEBS Letters, ISSN 0014-5793, E-ISSN 1873-3468, Vol. 591, no 22, p. 3781-3792Article in journal (Refereed) Published
Abstract [en]

Botulinum neurotoxins are highly toxic substances and are all encoded together with one of two alternative gene clusters, the HA or the OrfX gene cluster. Very little is known about the function and structure of the proteins encoded in the OrfX gene cluster, which in addition to the toxin contains five proteins (OrfX1, OrfX2, OrfX3, P47, and NTNH). We here present the structures of OrfX2 and P47, solved to 2.1 and 1.8 angstrom, respectively. We show that they belong to the TULIP protein superfamily, which are often involved in lipid binding. OrfX1 and OrfX2 were both found to bind phosphatidylinositol lipids.

Place, publisher, year, edition, pages
WILEY , 2017. Vol. 591, no 22, p. 3781-3792
Keywords [en]
botulinum neurotoxin, Crystallography, gene cluster, TULIP, X-ray
National Category
Biochemistry and Molecular Biology
Identifiers
URN: urn:nbn:se:umu:diva-143017DOI: 10.1002/1873-3468.12889ISI: 000416726600008OAI: oai:DiVA.org:umu-143017DiVA, id: diva2:1166174
Available from: 2017-12-14 Created: 2017-12-14 Last updated: 2018-06-09Bibliographically approved

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Berntsson, Ronnie P.-A.

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