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Softening of the Mouse Zona Pellucida during Oocyte Maturation
Umeå University, Faculty of Science and Technology, Centre for Biomedical Engineering and Physics (CMTF). College of Engineering, Nihon University, Koriyama, Fukushima, Japan; Luleå University, Luleå, Sweden.
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2013 (English)In: 2013 35TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC), IEEE , 2013, p. 6834-6837Conference paper, Published paper (Refereed)
Abstract [en]

A change in the elasticity and the resistance to dissolution of the mouse zona pellucida (ZP) was quantitatively evaluated at immature germinal vesicle (GV), mature metaphase II (MII) and fertilized pronuclear (PN) stages. Young's modulus of the ZP was measured using a micro tactile sensor (MTS), a highly sensitive resonator-based sensor for a micro scale elasticity measurement. 0.25% alpha-chymotrypsin was used for the ZP dissolution assay. The results of measuring the ZP elasticity and the dissolution time clearly showed that the ZP softened during oocyte maturation and the ZP hardened after fertilization. The results indicate that the amount of the zona softening can be a criterion to evaluate oocyte quality for the selection of top quality mature oocyte before in vitro fertilization (IVF) treatment.

Place, publisher, year, edition, pages
IEEE , 2013. p. 6834-6837
Series
IEEE Engineering in Medicine and Biology Society Conference Proceedings, ISSN 1557-170X
National Category
Medical Laboratory and Measurements Technologies
Identifiers
URN: urn:nbn:se:umu:diva-142772DOI: 10.1109/EMBC.2013.6611127ISI: 000341702107056ISBN: 978-1-4577-0216-7 OAI: oai:DiVA.org:umu-142772DiVA, id: diva2:1166660
Conference
35th Annual International Conference of the IEEE-Engineering-in-Medicine-and-Biology-Society (EMBC), JUL 03-07, 2013, Osaka, JAPAN
Available from: 2017-12-15 Created: 2017-12-15 Last updated: 2017-12-15Bibliographically approved

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CiteExportLink to record
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Citation style
  • apa
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  • Other style
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  • de-DE
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  • en-US
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  • nn-NO
  • nn-NB
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