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Environmental relevant levels of a benzodiazepine (oxazepam) alters important behavioral traits in a common planktivorous fish, (Rutilus rutilus)
Umeå University, Faculty of Science and Technology, Department of Ecology and Environmental Sciences.
Umeå University, Faculty of Science and Technology, Department of Ecology and Environmental Sciences.
Umeå University, Faculty of Science and Technology, Department of Ecology and Environmental Sciences.
Umeå University, Faculty of Science and Technology, Department of Ecology and Environmental Sciences.
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2017 (English)In: Journal of Toxicology and Environmental Health, ISSN 1528-7394, E-ISSN 1087-2620, Vol. 80, no 16–18, p. 963-970Article in journal (Refereed) Published
Abstract [en]

Environmental pollution by pharmaceuticals is increasingly recognized as a major threat to aquatic ecosystems worldwide. A complex mix of pharmaceuticals enters waterways via treated wastewater effluent and many remain biochemically active after the drugs reach aquatic systems. However, to date little is known regarding the ecological effects that might arise following pharmaceutical contamination of aquatic environments. One group of particular concern is behaviorally modifying pharmaceuticals as seemingly minor changes in behavior may initiate marked ecological consequences. The aim of this study was to examine the influence of a benzodiazepine anxiolytic drug (oxazepam) on key behavioral traits in wild roach (Rutilus rutilus) at concentrations similar to those encountered in effluent surface waters. Roach exposed to water with high concentrations of oxazepam (280 mu g/L) exhibited increased boldness, while roach at low treatment (0.84 mu g/L) became bolder and more active compared to control fish. Our results reinforce the notion that anxiolytic drugs may be affecting fish behavior in natural systems, emphasizing the need for further research on ecological impacts of pharmaceuticals in aquatic systems and development of new tools to incorporate ecologically relevant behavioral endpoints into ecotoxicological risk assessment.

Place, publisher, year, edition, pages
TAYLOR & FRANCIS INC , 2017. Vol. 80, no 16–18, p. 963-970
National Category
Environmental Sciences
Identifiers
URN: urn:nbn:se:umu:diva-143173DOI: 10.1080/15287394.2017.1352214ISI: 000416346600014PubMedID: 28829722OAI: oai:DiVA.org:umu-143173DiVA, id: diva2:1167951
Available from: 2017-12-19 Created: 2017-12-19 Last updated: 2018-06-09Bibliographically approved

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Brodin, TomasLagesson, AnnelieKlaminder, JonatanChristensen, BentFick, Jerker

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