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Ischemic stroke rates decline in patients with atrial fibrillation as anticoagulants uptake improves: A Swedish cohort study
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Medicine.
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2017 (English)In: Thrombosis Research, ISSN 0049-3848, E-ISSN 1879-2472, Vol. 158, p. 44-48Article in journal (Refereed) Published
Abstract [en]

Introduction: The impact of the increased anticoagulants uptake on incidence rate of ischemic stroke is largely unknown. We assessed time trends in rates of ischemic stroke in patients with incident atrial fibrillation (AF) diagnosed between 2011 and 2013.

Materials and methods: Population-based retrospective registry study of all 11,500 adults diagnosed with incident non-valvular atrial fibrillation in 2011-2013 in primary and secondary care and receiving oral anticoagulants (n = 4847), aspirin (n = 2850) or no treatment (n = 3766) in Skane County, Sweden. The primary outcome was the rate of ischemic stroke within 365 days after AF diagnosis.

Results and conclusion: Cumulative incidence of ischemic stroke decreased from 2.87% (95% confidence interval (CI) 2.37-3.45%) to 1.93% (95% CI 1.54-2.41%) while the uptake of oral anticoagulants increased from 36.6% to 48.4% between 2011 and 2013 (regression coefficient - 0.08; 95% CI, - 0.09 to - 0.07, p < 0.001). The increased uptake of oral anticoagulants in the community is associated with decreased incidence of ischemic stroke in AF patients.

Place, publisher, year, edition, pages
PERGAMON-ELSEVIER SCIENCE LTD , 2017. Vol. 158, p. 44-48
Keyword [en]
Anticoagulants, Atrial fibrillation, Cohort studies, Incidence, Stroke
National Category
Cardiac and Cardiovascular Systems
Identifiers
URN: urn:nbn:se:umu:diva-143160DOI: 10.1016/j.thromres.2017.08.004ISI: 000416505400009PubMedID: 28822239OAI: oai:DiVA.org:umu-143160DiVA, id: diva2:1168143
Available from: 2017-12-20 Created: 2017-12-20 Last updated: 2018-06-09Bibliographically approved

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Själander, Anders

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CiteExportLink to record
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Citation style
  • apa
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