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Increased plasma levels of soluble CD23 in haemorrhagic fever with renal syndrome; relation to virus-specific IgE.
Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Virology. (Fredrik Elgh)
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1997 (English)In: Clinical and Experimental Immunology, ISSN 0009-9104, E-ISSN 1365-2249, Vol. 109, no 2, p. 351-5Article in journal (Refereed) Published
Abstract [en]

In 15 consecutive patients hospitalized with nephropathia epidemica, a European form of haemorrhagic fever with renal syndrome (HFRS) caused by Puumala virus, plasma concentrations of soluble CD23 (sCD23) and Puumala virus-specific IgE were determined. In the acute phase of illness, 11/15 patients had increased sCD23 levels (> 91 U/ml), whereas in convalescence, values of 8/10 patients were normalized. Maximal sCD23 values were correlated to maximal concentrations of Puumala virus-specific serum IgE (r = 0.597; P = 0.025). The results are compatible with a known ability of sCD23 to augment IgE production.

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1997. Vol. 109, no 2, p. 351-5
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URN: urn:nbn:se:umu:diva-143299PubMedID: 9276532OAI: oai:DiVA.org:umu-143299DiVA, id: diva2:1168259
Available from: 2017-12-20 Created: 2017-12-20 Last updated: 2018-06-09

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