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Health Status Perspectives in Amyotrophic Lateral Sclerosis
Umeå University, Faculty of Medicine, Department of Pharmacology and Clinical Neuroscience, Clinical Neuroscience. Institute of Physiology, Institute of Molecular Medicine, Faculty of Medicine, University of Lisbon, Portugal.
2017 (English)In: Neurodegenerative Diseases, ISSN 1660-2854, E-ISSN 1660-2862, Vol. 17, no 6, p. 323-329Article in journal (Refereed) Published
Abstract [en]

Background/Aims: The global perception of the health status (HS) of amyotrophic lateral sclerosis (ALS) patients before the initial diagnosis has not been addressed previously. Methods: We recorded the following at the first visit, before diagnostic information: (1) visual analog scale (VAS) of the EQ-5D; (2) the revised ALS functional rating scale (ALSFRSR), bulbar (ALSFRSb), upper limb (ALSFRSul), lower limb (ALSFRSll), and respiratory (RofALSFRS-R) subscores; and (3) forced and slow vital capacities. Correlations were tested by the Pearson correlation test. Variables were compared between groups defined by the VAS median value. p < 0.05 was considered significant. Results: Of the 156 patients included in the study (91 spinal-onset, 49 bulbar-onset, 16 axial/respiratory- onset; 95 men; mean onset age 63.9 +/- 13 years; mean disease duration 18.4 +/- 26.5 months), HS VAS was significantly lower in spinal-onset patients (p = 0.047), and particularly in spinal-onset women (p = 0.027). Disease duration had no influence. HS VAS was moderately correlated with ALS-FRS, ALSFRSul and ALSFRSll (0.4 < r < 0.5, p < 0.01), weakly correlated with RofALSFRS-R in the whole population (r = 0.171, p < 0.05), and not correlated with ALSFRSb or the respiratory tests. ALSFRSb was similar between groups defined by the HS VAS median value, but the other scores were significantly lower for poorer HS values. Conclusion: HS before diagnosis is mostly dependent on the perception of upper and lower limb function. A tool tailored to evaluate HS in bulbar-onset patients should be developed.

Place, publisher, year, edition, pages
S. Karger, 2017. Vol. 17, no 6, p. 323-329
Keywords [en]
Amyotrophic lateral sclerosis, Quality of life, Health status, Health status visual analog scale, ALS functional rating scale
National Category
Neurology
Identifiers
URN: urn:nbn:se:umu:diva-143680DOI: 10.1159/000480638ISI: 000418304200011PubMedID: 29084402OAI: oai:DiVA.org:umu-143680DiVA, id: diva2:1170958
Available from: 2018-01-05 Created: 2018-01-05 Last updated: 2018-05-02Bibliographically approved

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