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Cord blood eicosanoid signatures and newborn gestational age
Umeå University, Faculty of Science and Technology, Department of Chemistry.
Umeå University, Faculty of Science and Technology, Department of Chemistry. Department of Entomology and Nematology, University of California, Davis, CA, USA.
2017 (English)In: Prostaglandins & other lipid mediators, ISSN 1098-8823, E-ISSN 2212-196X, Vol. 133, p. 123-127Article in journal (Refereed) Published
Abstract [en]

Beyond prostaglandins, the function of eicosanoids and other oxylipins in pregnancy and labor is poorly understood. In contrast to earlier work focusing on preterm infants, we investigated how oxylipin levels in newborns (measured in cord blood) vary during the last weeks of pregnancy in 190 mother-newborns (≥37 weeks of gestation) of the ENVIRONAGE birth cohort, Belgium. We found increased levels of PGE2 (p = 0.003), PGF (p = 0.042), 8,9-DHET (p = 0.037), 11-HETE (p = 0.034), and 15-HETrE (p = 0.008) associated with full term pregnancy compared to early term labor. Furthermore, late vs early term was associated with increased levels of PGE2 (p = 0.012) and TXB2 (p = 0.033), while late vs full term was associated with decreased levels of 14,15-DHET (p = 0.029), 11,12-DHET (p = 0.033), and 5-HETE (p = 0.045). To summarize, nine eicosanoids, derived via three enzymatic pathways, were significantly associated with gestational age. Eight of these were derived from arachidonic acid, and one from dihomo-γ-linolenic acid.

Place, publisher, year, edition, pages
Elsevier, 2017. Vol. 133, p. 123-127
Keyword [en]
Eicosanoids, Gestational age, Lipid metabolism, Mass spectrometry
National Category
Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)
Identifiers
URN: urn:nbn:se:umu:diva-143948DOI: 10.1016/j.prostaglandins.2017.07.003ISI: 000418729100017PubMedID: 28736329OAI: oai:DiVA.org:umu-143948DiVA, id: diva2:1174208
Conference
6th European Workshop on Lipid Mediators (EWLM), SEP 27-30, 2016, Goethe Univ, Frankfurt, GERMANY
Available from: 2018-01-15 Created: 2018-01-15 Last updated: 2018-06-09Bibliographically approved

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Gouveia-Figueira, Sandra

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