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The effects of Clopidogrel on neuroinflammation and learning impairment related to Alzheimer´s disease
Umeå University, Faculty of Medicine, Department of Medical Biosciences, Pathology.
2017 (English)Independent thesis Basic level (professional degree), 20 credits / 30 HE creditsStudent thesis
Abstract [en]

Neuroinflammation has been intensively studied the last two decades and has been shown to take part in neurodegenerative diseases such as Alzheimer’s disease (AD). The microglial cells, which are macrophages of the central nervous system (CNS), are the main actors in this chronic inflammatory state. Together with the neurons, the microglia are thought to control the complex dynamic remodeling of neuronal dendrites and synapses seen during both healthy and pathologic conditions. As a surface receptor of microglia, the purinergic receptor P2Y12 transmits intracellular signals for their chemotaxis towards tissue damage within the CNS. Clopidogrel, which is an inhibitor of P2Y12, is prescribed to patients with cerebrovascular diseases, which have high comorbidity with AD. In the present study, upregulated motor behavior, sensitization, has been studied in amyloid-beta (Aβ)-injected zebrafish larvae as a model for cognitive decline in AD. Although the behavioral experiments indicated a protective effect on learning from Clopidogrel in Aβ-injected fish, this effect was not reaching significance when several experiments were pooled together. Neuronal cell death numbers measured by confocal imaging showed an increase in Aβ-injected zebrafish larvae when treated with Clopidogrel. In conclusion, the experiments show that P2Y12 is important for removal of dead cells in the CNS of larval zebrafish following injury, and therefore could be relevant for neurodegenerative processes in humans.

Place, publisher, year, edition, pages
2017. , p. 27
National Category
Other Health Sciences
Identifiers
URN: urn:nbn:se:umu:diva-144257OAI: oai:DiVA.org:umu-144257DiVA, id: diva2:1178349
External cooperation
University of Gothenburg
Educational program
Medical Programme
Supervisors
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Available from: 2018-06-25 Created: 2018-01-29 Last updated: 2018-06-25Bibliographically approved

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Citation style
  • apa
  • ieee
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Output format
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  • asciidoc
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