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Lung function after extremely preterm birthA population-based cohort study (EXPRESS)
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Paediatrics.
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2018 (English)In: Pediatric Pulmonology, ISSN 8755-6863, E-ISSN 1099-0496, Vol. 53, no 1, p. 64-72Article in journal (Refereed) Published
Abstract [en]

Background and objectives: Follow-up studies of children and young adults born very-to-moderately preterm show persistent and significant lung function deficits. The aim of the study was to determine lung function and airway mechanics in school-aged children born in 2004 to 2007 and extremely preterm (after 22-26 weeks of gestation).

Methods: In a population-based cohort of children born extremely preterm and controls born at term (n=350), follow-up at 61/2-years-of-age was performed using spirometry and impulse oscillometry. Associations to gestational age, smallness for gestational age (SGA), and bronchopulmonary dysplasia (BPD) were assessed.

Results: Children born extremely preterm had lower forced vital capacity (FVC, z-score: -0.7, 95%CI: -1.0;-0.4), forced expiratory volume (FEV1, z-score: -1.1, 95%CI: -1.4; -0.8), higher frequency-dependence of resistance (R5-20, 0.09, 95%CI: 0.05; 0.12 kPaL(-1)s(-1)) and larger area under the reactance curve (AX, 0.78, 95%CI: 0.49; 1.07kPaL(-1)) than controls. In children born at 22-24 weeks of gestation, 24% had FVC and 44% had FEV1 below the lower limit of normal. SGA and severe BPD only marginally contributed to pulmonary outcomes. Asthma-like disease was reported in 40% of extremely preterm children and 15% of controls.

Conclusion: Many children born extremely preterm have altered airway mechanics and significant obstructive reduction in lung function. This warrants consideration for treatment and continued follow-up.

Place, publisher, year, edition, pages
WILEY , 2018. Vol. 53, no 1, p. 64-72
Keywords [en]
lung function tests, preterm birth, respiratory mechanics
National Category
Respiratory Medicine and Allergy Pediatrics
Identifiers
URN: urn:nbn:se:umu:diva-143630DOI: 10.1002/ppul.23919ISI: 000418247800013PubMedID: 29152899OAI: oai:DiVA.org:umu-143630DiVA, id: diva2:1178398
Available from: 2018-01-29 Created: 2018-01-29 Last updated: 2018-06-09Bibliographically approved

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Winberg, AnnaDomellöf, Magnus

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