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Healthy minds from 0-100 years: optimising the use of European brain imaging cohorts ("Lifebrain'')
Umeå universitet, Medicinska fakulteten, Umeå centrum för funktionell hjärnavbildning (UFBI).
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2018 (Engelska)Ingår i: European psychiatry, ISSN 0924-9338, E-ISSN 1778-3585, Vol. 50, s. 47-56Artikel, forskningsöversikt (Refereegranskat) Published
Abstract [en]

The main objective of "Lifebrain'' is to identify the determinants of brain, cognitive and mental (BCM) health at different stages of life. By integrating, harmonising and enriching major European neuroimaging studies across the life span, we will merge fine-grained BCM health measures of more than 5,000 individuals. Longitudinal brain imaging, genetic and health data are available for a major part, as well as cognitive and mental health measures for the broader cohorts, exceeding 27,000 examinations in total. By linking these data to other databases and biobanks, including birth registries, national and regional archives, and by enriching them with a new online data collection and novel measures, we will address the risk factors and protective factors of BCM health. We will identify pathways through which risk and protective factors work and their moderators. Exploiting existing European infrastructures and initiatives, we hope to make major conceptual, methodological and analytical contributions towards large integrative cohorts and their efficient exploitation. We will thus provide novel information on BCM health maintenance, as well as the onset and course of BCM disorders. This will lay a foundation for earlier diagnosis of brain disorders, aberrant development and decline of BCM health, and translate into future preventive and therapeutic strategies. Aiming to improve clinical practice and public health we will work with stakeholders and health authorities, and thus provide the evidence base for prevention and intervention.

Ort, förlag, år, upplaga, sidor
Elsevier, 2018. Vol. 50, s. 47-56
Nyckelord [en]
psychiatric disorder, dementia, economics and psychiatry, epidemiology, MRI, neurodevelopment
Nationell ämneskategori
Psykiatri
Identifikatorer
URN: urn:nbn:se:umu:diva-144404DOI: 10.1016/j.eurpsy.2017.12.006ISI: 000430263900008PubMedID: 29449073Scopus ID: 2-s2.0-8504478577OAI: oai:DiVA.org:umu-144404DiVA, id: diva2:1182360
Tillgänglig från: 2018-02-13 Skapad: 2018-02-13 Senast uppdaterad: 2018-09-12Bibliografiskt granskad

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Nyberg, Lars

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