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Comparative genomic analysis of Lactobacillus mucosae LM1 identifies potential niche-specific genes and pathways for gastrointestinal adaptation
Department of Animal Resources Science, Dankook University, Cheonan 31116, Republic of Korea.ORCID iD: 0000-0002-4396-346X
Dankook University.
Dankook University.
Seoul National University.
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2019 (English)In: Genomics, ISSN 0888-7543, E-ISSN 1089-8646, Vol. 111, no 1, p. 24-33Article in journal (Refereed) Published
Abstract [en]

Lactobacillus mucosae is currently of interest as putative probiotics due to their metabolic capabilities and ability to colonize host mucosal niches. L. mucosae LM1 has been studied in its functions in cell adhesion and pathogen inhibition, etc. It demonstrated unique abilities to use energy from carbohydrate and non-carbohydrate sources. Due to these functions, we report the first complete genome sequence of an L. mucosae strain, Lmucosae LM1. Analysis of the pan-genome in comparison with closely-related Lactobacillus species identified a complete glycogen metabolism pathway, as well as folate biosynthesis, complementing previous proteomic data on the LM1 strain. It also revealed common and unique niche-adaptation genes among the various L. mucosae strains. The aim of this study was to derive genomic information that would reveal the probable mechanisms underlying the probiotic effect of L. mucosae LM1, and provide a better understanding of the nature of L. mucosae sp.

Place, publisher, year, edition, pages
Elsevier, 2019. Vol. 111, no 1, p. 24-33
Keywords [en]
Lactobacillus mucosae, Comparative genomics, Probiotics
National Category
Microbiology
Identifiers
URN: urn:nbn:se:umu:diva-145020DOI: 10.1016/j.ygeno.2017.12.009ISI: 000455225100004OAI: oai:DiVA.org:umu-145020DiVA, id: diva2:1183455
Available from: 2018-02-16 Created: 2018-02-16 Last updated: 2019-01-28Bibliographically approved

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Valeriano, Valerie Diane

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