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Allopregnanolone involvement in feeding regulation, overeating and obesity
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Obstetrics and Gynecology.
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Obstetrics and Gynecology.
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Obstetrics and Gynecology.
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Obstetrics and Gynecology.
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2018 (English)In: Frontiers in neuroendocrinology (Print), ISSN 0091-3022, E-ISSN 1095-6808, Vol. 48, p. 70-77Article, review/survey (Refereed) Published
Abstract [en]

Obesity is strongly associated with ill health, primarily caused by consumption of excessive calories, and promoted (inter alia) by gamma-amino-butyric-acid (GABA) stimulating food intake by activating GABA(A) receptors (primarily with alpha 3 and alpha 2 subunits) in the hypothalamic arcuate nucleus and paraventricular nucleus. Allopregnanolone is a potent positive GABAA receptor modulating steroid (GAMS). As reviewed here, elevated allopregnanolone levels are associated with increases in food intake, preferences for energy-rich food, and obesity in humans and other mammals. In women with polycystic ovarian disease, high serum allopregnanolone concentrations are linked to uncontrolled eating, and perturbed sensitivity to allopregnanolone. Increases in weight during pregnancy also correlate with increases in allopregnanolone levels. Moreover, Prader-Willis syndrome is associated with massive overeating, absence of a GABA(A) receptor (with compensatory > 12-, > 5- and > 1.5-fold increases in alpha 4, gamma 2, and alpha 1, alpha 3 subunits), and increases in the alpha 4, beta x, delta receptor subtype, which is highly sensitive to allopregnanolone. GABA and positive GABA-A receptor modulating steroids like allopregnanolone stimulates food intake and weight gain.

Place, publisher, year, edition, pages
Academic Press, 2018. Vol. 48, p. 70-77
Keywords [en]
Allopregnanolone, GABA, GABA(A) receptor, Satiety, Hunger, Obesity, Overeating
National Category
Nutrition and Dietetics
Identifiers
URN: urn:nbn:se:umu:diva-145173DOI: 10.1016/j.yfrne.2017.07.002ISI: 000424316800008PubMedID: 28694181OAI: oai:DiVA.org:umu-145173DiVA, id: diva2:1189681
Available from: 2018-03-12 Created: 2018-03-12 Last updated: 2019-05-06Bibliographically approved

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Johansson, MajaTurkmen, SahruhBixo, MarieBäckström, Torbjörn

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