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A Study of Dynamic PET Frame-Binning on the Reference Logan Binding Potential
Umeå University, Faculty of Medicine, Department of Radiation Sciences, Radiation Physics.ORCID iD: 0000-0002-3353-6501
Umeå University, Faculty of Medicine, Department of Radiation Sciences, Radiation Physics.
Umeå University, Faculty of Medicine, Department of Radiation Sciences, Radiation Physics.
Umeå University, Faculty of Medicine, Department of Radiation Sciences, Diagnostic Radiology.
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2017 (English)In: IEEE Transactions on Radiation and Plasma Medical Sciences, ISSN 2469-7311, Vol. 1, no 2, p. 128-135Article in journal (Refereed) Published
Abstract [en]

Objective: The reference Logan plot is a tool for determining the non-displaceable binding potential for dynamic PET exams using tracers with reversible bindings. Dynamic frame protocols affect noise in PET images and short frames can lead to quantitative uncertainties and noise-induced reconstruction bias. The aim of this study was to analyze the effect of frame binning on 11C-Raclopride striatal binding potential from reference Logan analysis. Methods: 12 healthy volunteers were scanned in list mode using 11C-raclopride, and the image data were reconstructed into 9 different frame binning schemes whereof 3 clinical schemes. Reconstruction was performed with 3 different algorithms, one based on filtered back projection (FBP) and two based on ordered subset expectation maximization (OSEM); one including resolution recovery. Logan plots were used for calculating the non-displaceable binding potential. Variation in binding potential was evaluated using Students t-tests. Results: It was found that frame lengths of up to 60 s gave significantly different results compared to the reference clinical protocol for OSEM, both with and without resolution recovery (maximum deviation: 10.3 % for the 15 s protocol). For FBP, frame lengths of up to 30 s gave significantly different results with a maximum deviation of 2.8 %. The higher sampling dependence of OSEM compared to FBP is likely due to noise-dependent bias in the OSEM algorithm, most apparent at high noise levels. Conclusions: Bias related to OSEM reconstruction of high-noise data is an important factor for dynamic PET protocols. Time frames of 120 s or more generate the most stable values for the striatum binding potential with the reference Logan plot for 11C-Raclopride brain PET.

Place, publisher, year, edition, pages
2017. Vol. 1, no 2, p. 128-135
Keywords [en]
¹¹C-Raclopride, binding potential, dynamic frame protocol, frame binning, Logan analysis, positron emission tomography, time sampling
National Category
Radiology, Nuclear Medicine and Medical Imaging
Identifiers
URN: urn:nbn:se:umu:diva-146397DOI: 10.1109/TNS.2016.2639560OAI: oai:DiVA.org:umu-146397DiVA, id: diva2:1196116
Available from: 2018-04-09 Created: 2018-04-09 Last updated: 2018-06-09Bibliographically approved

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Wallstén, ElinAxelsson, JanKarlsson, MikaelRiklund, KatrineLarsson, Anne

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