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Relationship between QRS measurements and left ventricular morphology and function in asymptomatic individuals
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine. Molecular and Clinical Sciences Research Institute, St George University, London, UK.
2018 (English)In: Echocardiography, ISSN 0742-2822, E-ISSN 1540-8175, Vol. 35, no 3, p. 301-307Article in journal (Refereed) Published
Abstract [en]

Background and aim: QRS amplitude and duration are associated with increased left ventricular (LV) volume, mass and dysfunction. However, the diagnostic concordance between QRS measurements and LV morphology and function, as shown by Doppler echocardiography, is not well established. We investigated the relationships of QRS duration and amplitude with echocardiographic measurements of LV morphology and systolic and diastolic function in normal individuals.

Methods: Individuals without signs or symptoms of coronary artery disease or heart failure, who underwent clinical examination as a part of a cross-sectional survey for the prevalence of coronary risk factors, randomly selected from the population list in Caltanissetta, Italy, were included in the study. QRS duration and amplitude were automatically measured using inbuilt software. LV ejection and filling patterns were studied using Doppler echocardiography.

Results: We studied 184 individuals (96 men and 88 women), mean age 55.9 (11.3). QRS duration increased by 5.4ms for every 100g increase in LV mass, and by 4.6ms for each 10mm increase in LV end-diastolic diameter. The amplitude increased by 0.8mm for every 100g increase in LV mass. There was no relationship with LV dimensions. A nonlinear correlation was found between QRS amplitude and indexes of global dyssynchrony. The time-voltage QRS area correlated with LV mass, dimensions and indexes of dyssynchrony. There was no relationship between QRS measurements and ejection fraction.

Conclusions: QRS prolongation and increase in amplitude are strongly influenced by LV increased mass and volume, as well as by dyssynchrony, independently of ejection fraction.

Place, publisher, year, edition, pages
Wiley-Blackwell Publishing Inc., 2018. Vol. 35, no 3, p. 301-307
Keywords [en]
diastolic function, Doppler index of overall myocardial performance, ejection fraction, systolic nction, Tei index, ventricular function
National Category
Cardiac and Cardiovascular Systems
Identifiers
URN: urn:nbn:se:umu:diva-146233DOI: 10.1111/echo.13782ISI: 000426610300002PubMedID: 29280530OAI: oai:DiVA.org:umu-146233DiVA, id: diva2:1196382
Available from: 2018-04-09 Created: 2018-04-09 Last updated: 2018-06-09Bibliographically approved

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Henein, Michael

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