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A role for quorum sensing in regulating innate immune responses mediated by Vibrio cholerae outer membrane vesicles (OMVs).
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2011 (English)In: Gut microbes, ISSN 1949-0976, E-ISSN 1949-0984, Vol. 2, no 5, p. 274-9Article in journal (Refereed) Published
Abstract [en]

Outer membrane vesicles (OMVs) are released from many Gram-negative bacteria. OMVs interact with and are taken up by human cells. We and others have now showed that OMVs contain peptidoglycan, which is sensed mainly by the pattern-recognition receptor NOD1 in the cytoplasm of host cells. Vibrio cholerae is clinically important as one of the causative agents of severe dehydrating diarrhea in humans. We showed that non-O1 non-O139 V. cholerae (NOVC) strains of V. cholera produce OMVs. Of note, we revealed that NOVC can evade NOD1-mediated immune surveillance by the quorum sensing machinery. Here we review these recent findings and discuss the relevance for our understanding of bacterial infections and innate immune responses.

Place, publisher, year, edition, pages
2011. Vol. 2, no 5, p. 274-9
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Immunology
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URN: urn:nbn:se:umu:diva-146691DOI: 10.4161/gmic.2.5.18091PubMedID: 22067940OAI: oai:DiVA.org:umu-146691DiVA, id: diva2:1198499
Available from: 2018-04-17 Created: 2018-04-17 Last updated: 2018-06-11

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