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Hedgehog Signaling Regulates the Ciliary Transport of Odorant Receptors in Drosophila
Linköpings universitet, Avdelningen för cellbiologi.
Linköpings universitet, Avdelningen för cellbiologi.
Linköpings universitet, Avdelningen för cellbiologi.
Linköpings universitet, Avdelningen för cellbiologi.
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2016 (English)In: Cell reports, ISSN 2211-1247, E-ISSN 2211-1247, Vol. 14, no 3, p. 464-470Article in journal (Refereed) Published
Abstract [en]

Hedgehog (Hh) signaling is a key regulatory pathway during development and also has a functional role in mature neurons. Here, we show that Hh signaling regulates the odor response in adult Drosophila olfactory sensory neurons (OSNs). We demonstrate that this is achieved by regulating odorant receptor (OR) transport to and within the primary cilium in OSN neurons. Regulation relies on ciliary localization of the Hh signal transducer Smoothened (Smo). We further demonstrate that the Hh- and Smo-dependent regulation of the kinesin-like protein Cos2 acts in parallel to the intraflagellar transport system (IFT) to localize ORs within the cilium compartment. These findings expand our knowledge of Hh signaling to encompass chemosensory modulation and receptor trafficking.

Place, publisher, year, edition, pages
CELL PRESS , 2016. Vol. 14, no 3, p. 464-470
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Clinical Medicine
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URN: urn:nbn:se:umu:diva-146710DOI: 10.1016/j.celrep.2015.12.059ISI: 000368701600008PubMedID: 26774485OAI: oai:DiVA.org:umu-146710DiVA, id: diva2:1198584
Note

Funding Agencies|Swedish Foundation for Strategic Research [F06-0013]

Available from: 2018-04-18 Created: 2018-04-18 Last updated: 2018-06-09

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Granseth, BjörnAlenius, Mattias

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