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Plasma miRNA can detect colorectal cancer, but how early?
Umeå University, Faculty of Medicine, Department of Medical Biosciences, Pathology.
Umeå University, Faculty of Medicine, Department of Radiation Sciences, Oncology.
Umeå University, Faculty of Medicine, Department of Medical Biosciences, Pathology.
Umeå University, Faculty of Medicine, Department of Radiation Sciences, Oncology.ORCID iD: 0000-0002-9692-101x
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2018 (English)In: Cancer Medicine, ISSN 2045-7634, E-ISSN 2045-7634, Vol. 7, no 5, p. 1697-1705Article in journal (Refereed) Published
Abstract [en]

Colorectal cancer (CRC) is a major cause of deaths worldwide but has a good prognosis if detected early. The need for efficient, preferable non‐ or minimally invasive, inexpensive screening tools is therefore critical. We analyzed 12 miRNAs in pre‐ and postdiagnostic plasma samples to evaluate their potential as CRC screening markers. We used a unique study design with two overlapping cohorts, allowing analysis of pre‐ and postdiagnostic samples from 58 patients with CRC and matched healthy controls. Plasma concentrations of miR‐15b, ‐16, ‐18a, ‐19a, 21, ‐22, ‐25, ‐26a, ‐29c, ‐142‐5p, ‐150, and ‐192 were measured by semi‐quantitative real‐time PCR. Concentrations of miR‐18a, ‐21, ‐22, and ‐25 in plasma from patients with CRC were significantly altered compared to healthy controls. Combined as a multimarker panel, they detected CRC with an AUC of 0.93. Furthermore, levels of these three miRNAs also showed different levels in the prediagnostic case samples close to diagnosis. Only miR‐21‐levels were elevated several years before diagnosis. Plasma levels of miR‐18a, ‐21, ‐22, and ‐25 show promise as screening biomarkers for CRC. However, based on our unique analysis of prediagnostic and postdiagnostic samples from the same patients, we conclude that circulating miRNAs elevated at diagnosis may not automatically be suitable for CRC screening, if the increase occurs too close to clinical diagnosis.

Place, publisher, year, edition, pages
John Wiley & Sons, 2018. Vol. 7, no 5, p. 1697-1705
Keyword [en]
Colorectal cancer, early detection, plasma miRNA
National Category
Clinical Laboratory Medicine
Identifiers
URN: urn:nbn:se:umu:diva-146758DOI: 10.1002/cam4.1398ISI: 000431972900011PubMedID: 29573205Scopus ID: 2-s2.0-85044281770OAI: oai:DiVA.org:umu-146758DiVA, id: diva2:1198841
Available from: 2018-04-19 Created: 2018-04-19 Last updated: 2018-06-13Bibliographically approved

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Wikberg, Maria L.Myte, RobinPalmqvist, Richardvan Guelpen, BethanyLjuslinder, Ingrid

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