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Divergent functional roles of D-amino acids secreted by Vibrio cholerae
Umeå University, Faculty of Medicine, Molecular Infection Medicine Sweden (MIMS). Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine).
2017 (English)In: International Microbiology, ISSN 1139-6709, E-ISSN 1618-1905, Vol. 20, no 3, p. 149-150Article, review/survey (Refereed) Published
Abstract [en]

The L-forms of amino acids are used in all kingdoms of life to synthesize proteins. However, the bacterium Vibrio cholerae, the causative agent of cholera, produces D-amino acids which are released to the environment at millimolar concentrations. We baptized these D-amino acids as non-canonical D-amino acids (NCDAAs) since they are different from those (i.e. D-alanine and D-glutamate) normally present in the bacterial cell wall. In V. cholerae, production of NCDAAs relies on the BsrV enzyme, a periplasmic broad spectrum racemase. BsrV multispecific activity, produces of a wide range of distinct D-amino acids. Using a combination of genetics and molecular physiology approaches we have demonstrated that NCDAAs target different cellular processes which may function as part of a cooperative strategy in vibrio communities to protect non-producing members from competing bacteria. Because NCDAA production is widespread in bacteria, we anticipate that NCDAAs are relevant modulators of microbial subpopulations in diverse ecosystems.

Place, publisher, year, edition, pages
Institut d'Estudis Catalans , 2017. Vol. 20, no 3, p. 149-150
Keywords [en]
Vibrio cholerae, D-amino acids, cell wall, D-methionine, D-arginine
National Category
Microbiology in the medical area
Identifiers
URN: urn:nbn:se:umu:diva-147228DOI: 10.2436/20.1501.01.296ISI: 000429641600007PubMedID: 29446806OAI: oai:DiVA.org:umu-147228DiVA, id: diva2:1202899
Available from: 2018-05-02 Created: 2018-05-02 Last updated: 2018-06-09Bibliographically approved

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Cava, Felipe

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