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Effects of early nerve repair on experimental brachial plexus injury in neonatal rats
Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB). Department of Plastic and Reconstructive Surgery, Leeds Teaching Hospitals Trust, Leeds, UK.
Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences.
Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB). Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences. Department of Plastic and Reconstructive Surgery, Leeds Teaching Hospitals Trust, Leeds, UK.
Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB).
2018 (English)In: Journal of Hand Surgery, European Volume, ISSN 1753-1934, E-ISSN 2043-6289, Vol. 43, no 3, p. 275-281Article in journal (Refereed) Published
Abstract [en]

Obstetrical brachial plexus injury refers to injury observed at the time of delivery, which may lead to major functional impairment in the upper limb. In this study, the neuroprotective effect of early nerve repair following complete brachial plexus injury in neonatal rats was examined. Brachial plexus injury induced 90% loss of spinal motoneurons and 70% decrease in biceps muscle weight at 28 days after injury. Retrograde degeneration in spinal cord was associated with decreased density of dendritic branches and presynaptic boutons and increased density of astrocytes and macrophages/microglial cells. Early repair of the injured brachial plexus significantly delayed retrograde degeneration of spinal motoneurons and reduced the degree of macrophage/microglial reaction but had no effect on muscle atrophy. The results demonstrate that early nerve repair of neonatal brachial plexus injury could promote survival of injured motoneurons and attenuate neuroinflammation in spinal cord.

Place, publisher, year, edition, pages
Sage Publications, 2018. Vol. 43, no 3, p. 275-281
Keywords [en]
Brachial plexus injury, neonatal rat, spinal cord, motor neuron, cell death
National Category
Orthopaedics Surgery
Identifiers
URN: urn:nbn:se:umu:diva-147362DOI: 10.1177/1753193417732696ISI: 000429871600005PubMedID: 28950736OAI: oai:DiVA.org:umu-147362DiVA, id: diva2:1203590
Available from: 2018-05-03 Created: 2018-05-03 Last updated: 2018-06-09Bibliographically approved

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Bourke, GráinneMcGrath, Aleksandra M.Wiberg, MikaelNovikov, Lev N.

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Bourke, GráinneMcGrath, Aleksandra M.Wiberg, MikaelNovikov, Lev N.
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Department of Integrative Medical Biology (IMB)Department of Surgical and Perioperative Sciences
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Journal of Hand Surgery, European Volume
OrthopaedicsSurgery

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