umu.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Prognosis of sporadic resected small (≤2 cm) nonfunctional pancreatic neuroendocrine tumors: a multi-institutional study
Show others and affiliations
2018 (English)In: HPB, ISSN 1365-182X, E-ISSN 1477-2574, Vol. 20, no 3, p. 251-259Article in journal (Refereed) Published
Abstract [en]

Background: Malignant potential of small (<= 20 mm) nonfunctional pancreatic neuroendocrine tumors (sNF-PNET) is difficult to predict and management remain controversial. The aim of this study was to assess the prognosis of sporadic nonmetastatic sNF-PNETs.

Methods: Patients were identified from databases of 16 centers. Outcomes and risk factors for recurrence were identified by uni-and multivariate analyses.

Results: sNF-PNET was resected in 210 patients, and 66% (n = 138) were asymptomatic. Median age was 60 years, median tumor size was 15 mm, parenchyma-sparing surgery was performed in 42%. Postoperative mortality was 0.5% (n = 1), severe morbidity rate was 14.3% (n = 30), and 14 of 132 patients (10.6%) with harvested lymph nodes had metastatic lymph nodes. Tumor size, presence of biliary or pancreatic duct dilatation, and WHO grade 2-3 were independently associated with recurrence. Patients with tumors sized <= 10 mm were disease free at last follow-up. The 1-, 3- and 5-year disease-free survival rates for patients with tumors sized 11-20 mm on preoperative imaging were 95.1%, 91.0%, and 87.3%, respectively.

Conclusions: In sNF-PNETs, the presence of biliary or pancreatic duct dilatation or WHO grade 2-3 advocate for surgical treatment. In the remaining patients, a wait-and-see policy might be considered.

Place, publisher, year, edition, pages
Elsevier, 2018. Vol. 20, no 3, p. 251-259
National Category
Gastroenterology and Hepatology
Identifiers
URN: urn:nbn:se:umu:diva-146452DOI: 10.1016/j.hpb.2017.08.034ISI: 000427622300008PubMedID: 28988702OAI: oai:DiVA.org:umu-146452DiVA, id: diva2:1203608
Available from: 2018-05-03 Created: 2018-05-03 Last updated: 2018-06-09Bibliographically approved

Open Access in DiVA

fulltext(1188 kB)12 downloads
File information
File name FULLTEXT01.pdfFile size 1188 kBChecksum SHA-512
d139d675dd1ac3e59bd4da675aeb3b59655a110f91caf399422fb4baa1b7b7cdf11118cc4d06567207c8b997d3b090953adfd2005cc1ac00152241df1fbba904
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Authority records BETA

Franklin, Oskar

Search in DiVA

By author/editor
Franklin, Oskar
By organisation
Department of Surgical and Perioperative Sciences
In the same journal
HPB
Gastroenterology and Hepatology

Search outside of DiVA

GoogleGoogle Scholar
Total: 12 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 21 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf