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The Biology of CRISPR-Cas: Backward and Forward
Umeå University, Faculty of Medicine, Molecular Infection Medicine Sweden (MIMS). Umeå University, Faculty of Medicine, Umeå Centre for Microbial Research (UCMR). Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine). Department of Regulation in Infection Biology, Max Planck Institute for Infection Biology, Berlin, Germany; Institute for Biology, Humboldt University, Germany.
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2018 (English)In: Cell, ISSN 0092-8674, E-ISSN 1097-4172, Vol. 172, no 6, p. 1239-1259Article, review/survey (Refereed) Published
Abstract [en]

In bacteria and archaea, clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated (Cas) proteins constitute an adaptive immune system against phages and other foreign genetic elements. Here, we review the biology of the diverse CRISPR-Cas systems and the major progress achieved in recent years in understanding the underlying mechanisms of the three stages of CRISPR-Cas immunity: adaptation, crRNA biogenesis, and interference. The ecology and regulation of CRISPR-Cas in the context of phage infection, the roles of these systems beyond immunity, and the open questions that propel the field forward are also discussed.

Place, publisher, year, edition, pages
Elsevier, 2018. Vol. 172, no 6, p. 1239-1259
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Cell and Molecular Biology
Identifiers
URN: urn:nbn:se:umu:diva-146443DOI: 10.1016/j.cell.2017.11.032ISI: 000427482100026PubMedID: 29522745OAI: oai:DiVA.org:umu-146443DiVA, id: diva2:1203830
Available from: 2018-05-04 Created: 2018-05-04 Last updated: 2018-06-09Bibliographically approved

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Wong, Shi PeyCharpentier, Emmanuelle

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Wong, Shi PeyCharpentier, Emmanuelle
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Molecular Infection Medicine Sweden (MIMS)Umeå Centre for Microbial Research (UCMR)Department of Molecular Biology (Faculty of Medicine)
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