umu.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Structural changes in hand related cortical areas after median nerve injury and repair
Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB), Physiology. Umeå University, Faculty of Medicine, Umeå Centre for Functional Brain Imaging (UFBI). Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences, Hand Surgery.
Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences, Hand Surgery.
Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB), Physiology. Umeå University, Faculty of Medicine, Umeå Centre for Functional Brain Imaging (UFBI).
2018 (English)In: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 8, article id 4485Article in journal (Refereed) Published
Abstract [en]

Transection of the median nerve typically causes lifelong restriction of fine sensory and motor skills of the affected hand despite the best available surgical treatment. Inspired by recent findings on activity-dependent structural plasticity of the adult brain, we used voxel-based morphometry to analyze the brains of 16 right-handed adults who more than two years earlier had suffered injury to the left or right median nerve followed by microsurgical repair. Healthy individuals served as matched controls. Irrespective of side of injury, we observed gray matter reductions in left ventral and right dorsal premotor cortex, and white matter reductions in commissural pathways interconnecting those motor areas. Only left-side injured participants showed gray matter reduction in the hand area of the contralesional primary motor cortex. We interpret these effects as structural manifestations of reduced neural processing linked to restrictions in the diversity of the natural manual dexterity repertoire. Furthermore, irrespective of side of injury, we observed gray matter increases bilaterally in a motion-processing visual area. We interpret this finding as a consequence of increased neural processing linked to greater dependence on vision for control of manual dexterity after median nerve injury because of a compromised somatosensory innervation of the affected hand.

Place, publisher, year, edition, pages
Nature Publishing Group, 2018. Vol. 8, article id 4485
National Category
Neurosciences
Identifiers
URN: urn:nbn:se:umu:diva-146441DOI: 10.1038/s41598-018-22792-xISI: 000427366200015PubMedID: 29540748OAI: oai:DiVA.org:umu-146441DiVA, id: diva2:1203883
Available from: 2018-05-04 Created: 2018-05-04 Last updated: 2018-06-09Bibliographically approved

Open Access in DiVA

fulltext(8448 kB)9 downloads
File information
File name FULLTEXT01.pdfFile size 8448 kBChecksum SHA-512
bab874cd4fa6a50fc8c1672a5b1c8a88f5c52e8af05b661a75c6bc264b84ea35ef9ff2c8b20f66ebaf2fc4b5f9ec322f1e2e05f5b8d669cb0f8a39b8839b6b9a
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Authority records BETA

Nordmark, Per F.Ljungberg, ChristinaJohansson, Roland S.

Search in DiVA

By author/editor
Nordmark, Per F.Ljungberg, ChristinaJohansson, Roland S.
By organisation
PhysiologyUmeå Centre for Functional Brain Imaging (UFBI)Hand Surgery
In the same journal
Scientific Reports
Neurosciences

Search outside of DiVA

GoogleGoogle Scholar
Total: 9 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 12 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf