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Design and Biological Evaluation of Antifouling Dihydrostilbene Oxime Hybrids
Umeå University, Faculty of Science and Technology, Department of Chemistry. Department of Chemistry, UiT The Arctic University of Norway, Tromsø, Norway.
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2018 (English)In: Marine Biotechnology, ISSN 1436-2228, E-ISSN 1436-2236, Vol. 20, no 2, p. 257-267Article in journal (Refereed) Published
Abstract [en]

By combining the recently reported repelling natural dihydrostilbene scaffold with an oxime moiety found in many marine antifoulants, a library of nine antifouling hybrid compounds was developed and biologically evaluated. The prepared compounds were shown to display a low antifouling effect against marine bacteria but a high potency against the attachment and growth of microalgae down to MIC values of 0.01 μg/mL for the most potent hybrid. The mode of action can be characterized as repelling via a reversible non-toxic biostatic mechanism. Barnacle cyprid larval settlement was also inhibited at low μg/mL concentrations with low levels or no toxicity observed. Several of the prepared compounds performed better than many reported antifouling marine natural products. While several of the prepared compounds are highly active as antifoulants, no apparent synergy is observed by incorporating the oxime functionality into the dihydrostilbene scaffold. This observation is discussed in light of recently reported literature data on related marine natural antifoulants and antifouling hybrids as a potentially general strategy for generation of improved antifoulants.

Place, publisher, year, edition, pages
Springer, 2018. Vol. 20, no 2, p. 257-267
Keywords [en]
Antifouling, Dihydrostilbene, Batatasin, Oxime, Ianthelline, Hybrid
National Category
Microbiology Oceanography, Hydrology and Water Resources Environmental Biotechnology
Identifiers
URN: urn:nbn:se:umu:diva-147340DOI: 10.1007/s10126-018-9802-zISI: 000429402200012PubMedID: 29532333OAI: oai:DiVA.org:umu-147340DiVA, id: diva2:1205177
Available from: 2018-05-11 Created: 2018-05-11 Last updated: 2018-06-09Bibliographically approved

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Moodie, Lindon W. K.

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