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SNX18 regulates ATG9A trafficking from recycling endosomes by recruiting Dynamin-2
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2018 (English)In: EMBO Reports, ISSN 1469-221X, E-ISSN 1469-3178, Vol. 19, no 4, article id e44837Article in journal (Refereed) Published
Abstract [en]

Trafficking of mammalian ATG9A between the Golgi apparatus, endosomes and peripheral ATG9A compartments is important for autophagosome biogenesis. Here, we show that the membrane remodelling protein SNX18, previously identified as a positive regulator of autophagy, regulates ATG9A trafficking from recycling endosomes. ATG9A is recruited to SNX18-induced tubules generated from recycling endosomes and accumulates in juxtanuclear recycling endosomes in cells lacking SNX18. Binding of SNX18 to Dynamin-2 is important for ATG9A trafficking from recycling endosomes and for formation of ATG16L1- and WIPI2-positive autophagosome precursor membranes. We propose a model where upon autophagy induction, SNX18 recruits Dynamin-2 to induce budding of ATG9A and ATG16L1 containing membranes from recycling endosomes that traffic to sites of autophagosome formation.

Place, publisher, year, edition, pages
John Wiley & Sons, 2018. Vol. 19, no 4, article id e44837
Keywords [en]
ATG9, autophagy, dynamin, recycling endosome, SNX18
National Category
Cell and Molecular Biology
Identifiers
URN: urn:nbn:se:umu:diva-147339DOI: 10.15252/embr.201744837ISI: 000429540900006PubMedID: 29437695OAI: oai:DiVA.org:umu-147339DiVA, id: diva2:1205181
Available from: 2018-05-11 Created: 2018-05-11 Last updated: 2018-06-09Bibliographically approved

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Carlsson, Sven R.

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CiteExportLink to record
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  • apa
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