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IgE sensitization to food allergens and airborne allergens in relation to biomarkers of type 2 inflammation in asthma
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Medicine. Uppsala University, Department of Medical Sciences: Respiratory, Allergy and Sleep Research, Uppsala, Sweden; Uppsala University , Department of Medical Sciences: Clinical Physiology, Uppsala, Sweden.ORCID iD: 0000-0001-7837-1862
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2018 (English)In: Clinical and Experimental Allergy, ISSN 0954-7894, E-ISSN 1365-2222, Vol. 48, no 9, p. 1147-1154Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: We have recently reported that sensitisation to food allergens and sensitisation to airborne allergens had independent associations with increased fraction of exhaled nitric oxide (FeNO) and blood eosinophils in middle-aged adults and in young subjects with asthma.

OBJECTIVE: To investigate the relation between IgE sensitisation and several type 2 inflammation biomarkers in adult asthmatics.

METHODS: FeNO, urinary eosinophil-derived neurotoxin (U-EDN), serum eosinophil cationic protein (S-ECP) and periostin were measured in 396 asthmatics, aged 17-76 years, from the Swedish GA2LEN study. Sensitisation to airborne allergens was examined with skin prick tests (≥3 mm wheal) and sensitisation to food allergens with measurement of specific IgE (≥0.35kU/L).

RESULTS: Asthmatics sensitised to food allergens had higher FeNO, 22.3 ppb (18.6, 26.7) vs. 16.1 ppb (14.2, 18.2) (p=0.005), S-ECP, 17.7 mg/L (14.8, 21.1) vs. 12.8 mg/L (10.9, 14.9) (p=0.01), and periostin, 73.7 (67.5, 80.3) ng/mL vs. 59.9 (55.8, 64.2) ng/mL (p=0.003), than non-sensitised subjects. Periostin levels in this group were also significantly higher than in the group sensitised only to airborne allergens (p=0.01). Sensitisation to food allergens related independently to FeNO (p=0.02), S-ECP (p=0.006) and periostin (p=0.004), whereas sensitisation only to airborne allergens related only to FeNO (p=0.02) after adjustments for age, sex, height, weight and smoking history. FeNO correlated weakly with S-ECP (r=0.17, p<0.001), periostin (r=0.19, p<0.001) and U-EDN (0.16, p<0.001). S-ECP also correlated weakly with U-EDN (r=0.12, p=0.02). None of the correlations between the remaining pairs of markers of type 2 inflammation were significant.

CONCLUSIONS & CLINICAL RELEVANCE: Sensitisation to food allergens related to several local and systemic type 2 inflammation markers, such as FeNO, S-ECP and periostin. Assessing the profile of allergic sensitisation, including to food allergens, might improve the understanding and interpretation of inflammatory markers and potentially improve asthma management. 

Place, publisher, year, edition, pages
John Wiley & Sons, 2018. Vol. 48, no 9, p. 1147-1154
Keywords [en]
IgE sensitisation, airborne allergens, asthma, food allergens, type 2 inflammation
National Category
Respiratory Medicine and Allergy
Identifiers
URN: urn:nbn:se:umu:diva-147692DOI: 10.1111/cea.13165ISI: 000443113000006PubMedID: 29746003OAI: oai:DiVA.org:umu-147692DiVA, id: diva2:1205568
Funder
Västerbotten County CouncilSwedish Heart Lung FoundationSwedish Asthma and Allergy AssociationVårdal FoundationStockholm County CouncilSwedish Foundation for Strategic Research Available from: 2018-05-14 Created: 2018-05-14 Last updated: 2018-09-14Bibliographically approved

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Patelis, AntoniosForsberg, Bertil

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