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Elongator-a tRNA modifying complex that promotes efficient translational decoding
Umeå University, Faculty of Science and Technology, Department of Molecular Biology (Faculty of Science and Technology).
Umeå University, Faculty of Science and Technology, Department of Molecular Biology (Faculty of Science and Technology).
Umeå University, Faculty of Science and Technology, Department of Molecular Biology (Faculty of Science and Technology).
2018 (English)In: Biochimica et Biophysica Acta, ISSN 0006-3002, E-ISSN 1878-2434, Vol. 1861, no 4, p. 401-408Article in journal (Refereed) Published
Abstract [en]

Naturally occurring modifications of the nucleosides in the anticodon region of tRNAs influence their translational decoding properties. Uridines present at the wobble position in eukaryotic cytoplasmic tRNAs often contain a 5-carbamoylmethyl (ncm5) or 5-methoxycarbonylmethyl (mcm5) side-chain and sometimes also a 2-thio or 2'-O-methyl group. The first step in the formation of the ncm5 and mcm5 side-chains requires the conserved six-subunit Elongator complex. Although Elongator has been implicated in several different cellular processes, accumulating evidence suggests that its primary, and possibly only, cellular function is to promote modification of tRNAs. In this review, we discuss the biosynthesis and function of modified wobble uridines in eukaryotic cytoplasmic tRNAs, focusing on the in vivo role of Elongator-dependent modifications in Saccharomyces cerevisiae. 

Place, publisher, year, edition, pages
2018. Vol. 1861, no 4, p. 401-408
National Category
Biochemistry and Molecular Biology
Identifiers
URN: urn:nbn:se:umu:diva-147685DOI: 10.1016/j.bbagrm.2017.11.006ISI: 000430523900013PubMedID: 29170010OAI: oai:DiVA.org:umu-147685DiVA, id: diva2:1208721
Funder
Swedish Research Council, 621-2016-03949Available from: 2018-05-18 Created: 2018-05-18 Last updated: 2018-06-09Bibliographically approved

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Johansson, Marcus J OXu, FuByström, Anders S

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