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A synbiotic-containing amino-acid-based formula improves gut microbiota in non-IgE-mediated allergic infants
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2018 (English)In: Pediatric Research, ISSN 0031-3998, E-ISSN 1530-0447, Vol. 83, no 3, p. 677-686Article in journal (Refereed) Published
Abstract [en]

Background: Prebiotics and probiotics (synbiotics) can modify gut microbiota and have potential in allergy management when combined with amino-acid-based formula (AAF) for infants with cow’s milk allergy (CMA).

Methods: This multicenter, double-blind, randomized controlled trial investigated the effects of an AAF-including synbiotic blend on percentages of bifidobacteria and Eubacterium rectale/Clostridium coccoides group (ER/CC) in feces from infants with suspected non-IgE-mediated CMA. Feces from age-matched healthy breastfed infants were used as reference (healthy breastfed reference (HBR)) for primary outcomes. The CMA subjects were randomized and received test or control formula for 8 weeks. Test formula was a hypoallergenic, nutritionally complete AAF including a prebiotic blend of fructo-oligosaccharides and the probiotic strain Bifidobacterium breve M-16V. Control formula was AAF without synbiotics.

Results: A total of 35 (test) and 36 (control) subjects were randomized; HBR included 51 infants. At week 8, the median percentage of bifidobacteria was higher in the test group than in the control group (35.4% vs. 9.7%, respectively; P<0.001), whereas ER/CC was lower (9.5% vs. 24.2%, respectively; P<0.001). HBR levels of bifidobacteria and ER/CC were 55% and 6.5%, respectively.

Conclusion: AAF including specific synbiotics, which results in levels of bifidobacteria and ER/CC approximating levels in the HBR group, improves the fecal microbiota of infants with suspected non-IgE-mediated CMA.

Place, publisher, year, edition, pages
2018. Vol. 83, no 3, p. 677-686
National Category
Pediatrics
Identifiers
URN: urn:nbn:se:umu:diva-147477DOI: 10.1038/pr.2017.270ISI: 000430304300018PubMedID: 29155807OAI: oai:DiVA.org:umu-147477DiVA, id: diva2:1208956
Available from: 2018-05-21 Created: 2018-05-21 Last updated: 2018-06-09Bibliographically approved

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West, Christina E.

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