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Chronic airway obstruction in a population-based adult asthma cohort: Prevalence, incidence and prognostic factors.
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Occupational and Environmental Medicine. (the OLIN Unit, Umeå University, Umeå, Sweden.)
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Occupational and Environmental Medicine. (the OLIN Unit, Umeå University, Umeå, Sweden.)
Department of Health Sciences, Luleå University, Luleå, Sweden..
Real-World Evidence&Epidemiology, GSK R&D, Uxbridge, UK..
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2018 (English)In: Respiratory Medicine, ISSN 0954-6111, E-ISSN 1532-3064, Vol. 138, p. 115-122, article id S0954-6111(18)30108-2Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Asthma and COPD may overlap (ACO) but information about incidence and risk factors are lacking. This study aimed to estimate prevalence, incidence and risk factors of chronic airway obstruction (CAO) in a population-based adult asthma cohort.

METHODS: /FVC<0.7.

RESULTS: decline and higher levels of neutrophils than asthma only. Smoking, older age and male sex were independently associated with increased risk for both prevalent and incident CAO, while obesity had a protective effect.

CONCLUSIONS: In this prospective adult asthma cohort, the majority did not develop CAO. Smoking, older age and male sex were risk factors for prevalent and incident CAO, similar to risk factors described for COPD in the general population.

Place, publisher, year, edition, pages
2018. Vol. 138, p. 115-122, article id S0954-6111(18)30108-2
Keywords [en]
ACO, Asthma, Epidemiology, Longitudinal study, Risk factors
Identifiers
URN: urn:nbn:se:umu:diva-147915DOI: 10.1016/j.rmed.2018.03.036PubMedID: 29724382OAI: oai:DiVA.org:umu-147915DiVA, id: diva2:1209150
Available from: 2018-05-22 Created: 2018-05-22 Last updated: 2018-06-09

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Backman, HelenaJansson, Sven-ArneHedman, LinneaRönmark, Eva

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