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Contact (kallikrein/kinin) system activation in whole human blood induced by low concentrations of alpha-Fe2O3 nanoparticles
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2018 (English)In: Nanomedicine: Nanotechnology, Biology and Medicine, ISSN 1549-9634, E-ISSN 1549-9642, Vol. 14, no 3, p. 735-744Article in journal (Refereed) Published
Abstract [en]

Iron-oxide nanoparticles (NPs) generated by environmental events are likely to represent health problems. α-Fe2O3 NPs were synthesized, characterized and tested in a model for toxicity utilizing human whole blood without added anticoagulant. MALDI-TOF of the corona was performed and activation markers for plasma cascade systems (complement, contact and coagulation systems), platelet consumption and release of growth factors, MPO, and chemokine/cytokines from blood cells were analyzed. The coronas formed on the pristine α-Fe2O3 NPs contained contact system proteins and they induced massive activation of the contact (kinin/kallikrein) system, as well as thrombin generation, platelet activation, and release of two pro-angiogeneic growth factors: platelet-derived growth factor and vascular endothelial growth factor, whereas complement activation was unaffected. The α-Fe2O3 NPs exhibited a noticeable toxicity, with kinin/kallikrein activation, which may be associated with hypotension and long-term angiogenesis in vivo, with implications for cancer, arteriosclerosis and pulmonary disease.

Place, publisher, year, edition, pages
Elsevier, 2018. Vol. 14, no 3, p. 735-744
Keywords [en]
α-Fe2O3 NPs, Contact/kallikrein system, Innate immunity
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
URN: urn:nbn:se:umu:diva-147323DOI: 10.1016/j.nano.2017.12.008ISI: 000429528900010PubMedID: 29277639OAI: oai:DiVA.org:umu-147323DiVA, id: diva2:1209326
Available from: 2018-05-22 Created: 2018-05-22 Last updated: 2018-06-09Bibliographically approved

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Bucht, AndersNilsson, Bo

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  • apa
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