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The retrosplenial cortex: a memory gateway between the cortical default mode network and the medial temporal lobe
Umeå University, Faculty of Medicine, Umeå Centre for Functional Brain Imaging (UFBI). Aging Research Center, Karolinska Institutet, Stockholm, Sweden.ORCID iD: 0000-0002-0264-6839
Umeå University, Faculty of Medicine, Umeå Centre for Functional Brain Imaging (UFBI). Umeå University, Faculty of Medicine, Department of Radiation Sciences. Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB).
Umeå University, Faculty of Medicine, Umeå Centre for Functional Brain Imaging (UFBI). Aging Research Center, Karolinska Institutet, Stockholm, Sweden.ORCID iD: 0000-0002-4675-8437
2018 (English)In: Human Brain Mapping, ISSN 1065-9471, E-ISSN 1097-0193, Vol. 39, no 5, p. 2020-2034Article in journal (Refereed) Published
Abstract [en]

The default mode network (DMN) involves interacting cortical areas, including the posterior cingulate cortex (PCC) and the retrosplenial cortex (RSC), and subcortical areas, including the medial temporal lobe (MTL). The degree of functional connectivity (FC) within the DMN, particularly between MTL and medial-parietal subsystems, relates to episodic memory (EM) processes. However, past resting-state studies investigating the link between posterior DMN-MTL FC and EM performance yielded inconsistent results, possibly reflecting heterogeneity in the degree of connectivity between MTL and specific cortical DMN regions. Animal work suggests that RSC has structural connections to both cortical DMN regions and MTL, and may thus serve as an intermediate layer that facilitates information transfer between cortical and subcortical DMNs. We studied 180 healthy old adults (aged 64-68 years), who underwent comprehensive assessment of EM, along with resting-state fMRI. We found greater FC between MTL and RSC than between MTL and the other cortical DMN regions (e.g., PCC), with the only significant association with EM observed for MTL-RSC FC. Mediational analysis showed that MTL-cortical DMN connectivity increased with RSC as a mediator. Further analysis using a graph-theoretical approach on DMN nodes revealed the highest betweenness centrality for RSC, confirming that a high proportion of short paths among DMN regions pass through RSC. Importantly, the degree of RSC mediation was associated with EM performance, suggesting that individuals with greater mediation have an EM advantage. These findings suggest that RSC forms a critical gateway between MTL and cortical DMN to support EM in older adults.

Place, publisher, year, edition, pages
John Wiley & Sons, 2018. Vol. 39, no 5, p. 2020-2034
Keywords [en]
aging, betweenness centrality, DMN, episodic memory, medial temporal lobe, multilevel meditation, retrosplenial cortex
National Category
Neurology Neurosciences Radiology, Nuclear Medicine and Medical Imaging
Identifiers
URN: urn:nbn:se:umu:diva-147289DOI: 10.1002/hbm.23983ISI: 000429710500011PubMedID: 29363256OAI: oai:DiVA.org:umu-147289DiVA, id: diva2:1210093
Available from: 2018-05-25 Created: 2018-05-25 Last updated: 2018-06-09Bibliographically approved

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Kaboodvand, NedaNyberg, LarsSalami, Alireza

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Umeå Centre for Functional Brain Imaging (UFBI)Department of Radiation SciencesDepartment of Integrative Medical Biology (IMB)
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