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New Insights Into the Mechanisms and Biological Roles of D-Amino Acids in Complex Eco-Systems
Umeå University, Faculty of Medicine, Molecular Infection Medicine Sweden (MIMS). Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine).
Umeå University, Faculty of Medicine, Molecular Infection Medicine Sweden (MIMS). Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine).
Umeå University, Faculty of Medicine, Molecular Infection Medicine Sweden (MIMS). Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine).
2018 (English)In: Frontiers in Microbiology, ISSN 1664-302X, E-ISSN 1664-302X, Vol. 9, article id 683Article, review/survey (Refereed) Published
Abstract [en]

In the environment bacteria share their habitat with a great diversity of organisms, from microbes to humans, animals and plants. In these complex communities, the production of extracellular effectors is a common strategy to control the biodiversity by interfering with the growth and/or viability of nearby microbes. One of such effectors relies on the production and release of extracellular D-amino acids which regulate diverse cellular processes such as cell wall biogenesis, biofilm integrity, and spore germination. Non-canonical D-amino acids are mainly produced by broad spectrum racemases (Bsr). Bsr's promiscuity allows it to generate high concentrations of D-amino acids in environments with variable compositions of L-amino acids. However, it was not clear until recent whether these molecules exhibit divergent functions. Here we review the distinctive biological roles of D-amino acids, their mechanisms of action and their modulatory properties of the biodiversity of complex eco-systems.

Place, publisher, year, edition, pages
Frontiers Media S.A., 2018. Vol. 9, article id 683
Keywords [en]
D-amino acids, D-methionine, D-arginine, bacteria, cell wall, Vibrio cholerae
National Category
Microbiology in the medical area
Identifiers
URN: urn:nbn:se:umu:diva-147303DOI: 10.3389/fmicb.2018.00683ISI: 000429347700001PubMedID: 29681896OAI: oai:DiVA.org:umu-147303DiVA, id: diva2:1210336
Available from: 2018-05-28 Created: 2018-05-28 Last updated: 2018-06-09Bibliographically approved

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Aliashkevich, AlenaAlvarez, LauraCava, Felipe

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Aliashkevich, AlenaAlvarez, LauraCava, Felipe
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