umu.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
A Toll-like receptor 2-integrin beta3 complex senses bacterial lipopeptides via vitronectin.
Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Virology. (Gisa Gerold)
Show others and affiliations
2008 (English)In: Nature Immunology, ISSN 1529-2908, E-ISSN 1529-2916, Vol. 9, no 7, p. 761-8Article in journal (Refereed) Published
Abstract [en]

Toll-like receptor 2 (TLR2) initiates inflammation in response to bacterial lipopeptide (BLP). However, the molecular mechanisms enabling the detection of BLP by TLR2 are unknown. Here we investigated the interaction of BLP with human serum proteins and identified vitronectin as a BLP-recognition molecule. Vitronectin and its receptor, integrin beta(3), were required for BLP-induced TLR2-mediated activation of human monocytes. Furthermore, monocytes from patients with Glanzmann thrombasthenia, which lack integrin beta(3), were completely unresponsive to BLP. In addition, integrin beta(3) formed a complex with TLR2 and this complex dissociated after BLP stimulation. Notably, vitronectin and integrin beta(3) coordinated responses to other TLR2 agonists such as lipoteichoic acid and zymosan. Our findings show that vitronectin and integrin beta(3) contribute to the initiation of TLR2 responses.

Place, publisher, year, edition, pages
2008. Vol. 9, no 7, p. 761-8
Identifiers
URN: urn:nbn:se:umu:diva-148149DOI: 10.1038/ni.1618PubMedID: 18516040OAI: oai:DiVA.org:umu-148149DiVA, id: diva2:1210756
Available from: 2018-05-29 Created: 2018-05-29 Last updated: 2018-06-09

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textPubMed

Authority records BETA

Gerold, Gisa

Search in DiVA

By author/editor
Gerold, Gisa
By organisation
Virology
In the same journal
Nature Immunology

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 2 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf