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What is the role of Toll-like receptors in bacterial infections?
Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Virology. (Gisa Gerold)
2007 (English)In: Seminars in Immunology, ISSN 1044-5323, E-ISSN 1096-3618, Vol. 19, no 1, p. 41-7Article in journal (Refereed) Published
Abstract [en]

Innate immunity relies on signalling by Toll-like receptors (TLRs) to alert the immune system of the presence of invading bacteria. TLR activation leads to the release of cytokines that allow for effective innate and adaptive immune responses. However, the contribution of different TLRs depends on the site of the infection and the pathogen. This review will describe the involvement of TLRs in the development of three different bacterial infections as well as our current understanding of the role of TLRs during microbial pathogenesis.

Place, publisher, year, edition, pages
2007. Vol. 19, no 1, p. 41-7
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URN: urn:nbn:se:umu:diva-148171DOI: 10.1016/j.smim.2006.12.003PubMedID: 17280841OAI: oai:DiVA.org:umu-148171DiVA, id: diva2:1210811
Available from: 2018-05-29 Created: 2018-05-29 Last updated: 2018-06-09

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