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Left Ventricular Isovolumetric Relaxation Time Is Prolonged in Fetal Long-QT Syndrome
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2018 (English)In: Circulation: Arrhythmia and Electrophysiology, ISSN 1941-3149, E-ISSN 1941-3084, Vol. 11, no 4, article id e005797Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Long-QT syndrome (LQTS), an inherited cardiac repolarization disorder, is an important cause of fetal and neonatal mortality. Detecting LQTS prenatally is challenging. A fetal heart rate (FHR) less than third percentile for gestational age is specific for LQTS, but the sensitivity is only ≈50%. Left ventricular isovolumetric relaxation time (LVIRT) was evaluated as a potential diagnostic marker for fetal LQTS.

METHODS AND RESULTS: <0.001), as was the N-LVIRT. The best cutoff to diagnose LQTS was N-LVIRT ≥11.3 at ≤20 weeks (92% sensitivity, 70% specificity). Simultaneous analysis of N-LVIRT and FHR improved the sensitivity and specificity for LQTS (area under the curve=0.96; 95% confidence interval, 0.82-1.00 at 21-30 weeks). N-LVIRT, LV myocardial performance index, and FHR trends differed significantly between LQTS fetuses and controls through gestation.

CONCLUSIONS: The LVIRT is prolonged in LQTS fetuses. Findings of a prolonged N-LVIRT and sinus bradycardia can improve the prenatal detection of fetal LQTS.

Place, publisher, year, edition, pages
Lippincott Williams & Wilkins, 2018. Vol. 11, no 4, article id e005797
Keywords [en]
Doppler, fetus, gestational age, heart rate, isovolumetric relaxation time, long QT syndrome, prenatal diagnosis
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Pediatrics
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URN: urn:nbn:se:umu:diva-148431DOI: 10.1161/CIRCEP.117.005797PubMedID: 29654130OAI: oai:DiVA.org:umu-148431DiVA, id: diva2:1213762
Available from: 2018-06-05 Created: 2018-06-05 Last updated: 2018-10-29Bibliographically approved

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Rydberg, Annika

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CiteExportLink to record
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