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Platelet RNA in Cancer Diagnostics
Umeå University, Faculty of Medicine, Department of Radiation Sciences, Oncology.
Umeå University, Faculty of Medicine, Department of Radiation Sciences, Oncology.
2018 (English)In: Seminars in Thrombosis and Hemostasis, ISSN 0094-6176, E-ISSN 1098-9064, Vol. 44, no 2, p. 135-141Article in journal (Refereed) Published
Abstract [en]

Platelets are involved in several steps of cancer metastasis. During this process, platelets are exposed to the tumor and its environment, thereby exchanging biomolecules with the tumor cells and resulting in tumor-mediated education of the platelets and a change in their RNA profile. Analysis of platelet RNA profiles or direct measurement of tumor-derived biomarkers within platelets can provide information on ongoing cancer-related processes in the individual (e.g., whether the patient has cancer, the tumor type, and possibly identify oncogenic alterations driving the disease for treatment selection). The close interaction with the disease process and the ability to respond to systemic alterations make platelets an interesting biosource for implementation in precision medicine.

Place, publisher, year, edition, pages
THIEME MEDICAL PUBL INC , 2018. Vol. 44, no 2, p. 135-141
Keywords [en]
platelets, biomarkers, liquid biopsy
National Category
Cancer and Oncology
Identifiers
URN: urn:nbn:se:umu:diva-145772DOI: 10.1055/s-0037-1606182ISI: 000426118100007PubMedID: 28905353Scopus ID: 2-s2.0-85029755219OAI: oai:DiVA.org:umu-145772DiVA, id: diva2:1220072
Available from: 2018-06-18 Created: 2018-06-18 Last updated: 2018-06-18Bibliographically approved

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Tjon-Kon-Fat, Lee-AnnNilsson, R. Jonas A.

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