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Influence of obesity-related risk factors in the aetiology of glioma
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2018 (English)In: British Journal of Cancer, ISSN 0007-0920, E-ISSN 1532-1827, Vol. 118, no 7, p. 1020-1027Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Obesity and related factors have been implicated as possible aetiological factors for the development of glioma in epidemiological observation studies. We used genetic markers in a Mendelian randomisation framework to examine whether obesity-related traits influence glioma risk. This methodology reduces bias from confounding and is not affected by reverse causation. METHODS: Genetic instruments were identified for 10 key obesity-related risk factors, and their association with glioma risk was evaluated using data from a genome-wide association study of 12,488 glioma patients and 18,169 controls. The estimated odds ratio of glioma associated with each of the genetically defined obesity-related traits was used to infer evidence for a causal relationship. RESULTS: No convincing association with glioma risk was seen for genetic instruments for body mass index, waist-to-hip ratio, lipids, type-2 diabetes, hyperglycaemia or insulin resistance. Similarly, we found no evidence to support a relationship between obesity-related traits with subtypes of glioma-glioblastoma (GBM) or non-GBM tumours. CONCLUSIONS: This study provides no evidence to implicate obesity-related factors as causes of glioma.

Place, publisher, year, edition, pages
Nature Publishing Group, 2018. Vol. 118, no 7, p. 1020-1027
National Category
Endocrinology and Diabetes
Identifiers
URN: urn:nbn:se:umu:diva-148648DOI: 10.1038/s41416-018-0009-xISI: 000429279300013PubMedID: 29531326Scopus ID: 2-s2.0-85043501357OAI: oai:DiVA.org:umu-148648DiVA, id: diva2:1223596
Available from: 2018-06-25 Created: 2018-06-25 Last updated: 2018-06-25Bibliographically approved

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Melin, Beatrice S.

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